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Related Concept Videos

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The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
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The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
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Updated: Feb 17, 2026

Profiling the Triacylglyceride Contents in Bat Integumentary Lipids by Preparative Thin Layer Chromatography and MALDI-TOF Mass Spectrometry
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Analysis of sensitive skin barrier function: basic indicators and sebum composition.

L Fan1,2, Y Jia1,2, L Cui1,2

  • 1School of Science/Key Laboratory of Cosmetic, China National Light Industry, Beijing Technology and Business University, Beijing, 100048, China.

International Journal of Cosmetic Science
|December 8, 2017
PubMed
Summary
This summary is machine-generated.

Sensitive skin (SS) in women is linked to altered sebum composition, including higher ceramides and lower glucosylceramides. This suggests barrier dysfunction may cause SS, highlighting the need for targeted skincare research.

Keywords:
lipid compositionphysiological indicatorssensitive skinskin barrier

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Area of Science:

  • Dermatology
  • Biochemistry
  • Cosmetic Science

Background:

  • Sensitive skin (SS) is prevalent, characterized by high reactivity and low tolerance.
  • Increasing public awareness of skincare drives research into skin conditions like SS.
  • Environmental changes and marketing influence consumer attention to skin health.

Purpose of the Study:

  • To investigate the differences in skin barrier components between sensitive skin (SS) and normal skin (NS).
  • To identify specific lipid profiles in facial sebum associated with SS in women.

Main Methods:

  • Utilized a questionnaire survey to gather data on skin conditions.
  • Analyzed basic skin barrier indicators, including sebum secretion.
  • Employed ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) for facial sebum component identification.

Main Results:

  • Sensitive skin (SS) exhibited lower overall sebum secretion compared to normal skin (NS).
  • Facial sebum in women with SS showed elevated levels of ceramides, glycerophosphoethanolamines, and diacylglycerols.
  • Conversely, glucosylceramides, glycerophosphoserines, glycerophosphocholines, and triacylglycerols were found at lower levels in SS sebum.

Conclusions:

  • Sensitive skin (SS) in women may stem from skin barrier dysfunction, potentially due to excessive apoptosis and dehydration.
  • Further research into cosmetic additives that inhibit keratinocyte apoptosis is recommended.
  • Developing methods to enhance skin water molecule stability is crucial for managing SS.