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Mining Plants for Bacterial Quorum Sensing Modulators.

Shimrit David¹, Aviad Mandabi¹, Shaked Uzi¹

¹Department of Chemistry and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev , Be'er-Sheva, Israel.

ACS Chemical Biology

|December 8, 2017

Summary

Agrobacterium tumefaciens causes crown gall tumors by transferring DNA into plants. Researchers screened 3800 natural products, finding compounds that can modulate these harmful plant-bacterial interactions.

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Area of Science:

Microbiology
Plant Pathology
Natural Products Chemistry

Background:

Agrobacterium tumefaciens is a bacterial plant pathogen responsible for crown gall tumors.
The pathogen utilizes quorum sensing (QS) to regulate DNA transfer into host plant genomes, leading to tumor formation.
These infections negatively impact numerous fruit and crop species.

Purpose of the Study:

To understand the mechanisms of Agrobacterium tumefaciens-mediated plant infections.
To identify natural compounds that can interfere with plant-bacterial interactions.
To develop potential solutions for controlling crown gall disease.

Main Methods:

Screening of a library containing 3800 natural products derived from plant sources.
Evaluation of the identified compounds for their ability to modulate plant-bacterial interactions.
Assessing the efficacy of compounds in interfering with Agrobacterium tumefaciens virulence.

Main Results:

Identification of potent natural compounds capable of modulating plant-bacterial interactions.
Discovery of specific compounds that significantly inhibit Agrobacterium tumefaciens-induced crown gall formation.
Demonstration of natural products as viable modulators of plant pathogen virulence.

Conclusions:

Natural products offer a promising avenue for controlling Agrobacterium tumefaciens infections.
Compounds identified can disrupt the quorum sensing-regulated virulence of this important plant pathogen.
Further research into these compounds could lead to novel strategies for crop protection.