Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autoradiography of 90Sr in developing rats.

I Olsen, J Jonsen

    Scandinavian Journal of Dental Research
    |April 1, 1979
    PubMed
    Summary

    Strontium-90 (90Sr) initially distributes to soft tissues, then accumulates in hard tissues like bone and teeth over 72 hours. Teeth show a strong correlation with bone uptake, indicating their potential as 90Sr bioindicators.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Low levels of antibodies for the oral bacterium Tannerella forsythia predict cardiovascular disease mortality in men with myocardial infarction: A prospective cohort study.

    Medical hypotheses·2020
    Same author

    Expression of growth mediators in the gingival crevicular fluid of patients with aggressive periodontitis undergoing periodontal surgery.

    Clinical oral investigations·2018
    Same author

    New promising β-lactamase inhibitors for clinical use.

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2015
    Same author

    Biofilm-specific antibiotic tolerance and resistance.

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2015
    Same author

    Intestinal strictures, fibrous adhesions and high local interleukin-10 levels in goats infected naturally with Mycobacterium avium subsp. paratuberculosis.

    Journal of comparative pathology·2012
    Same author

    Human papillomavirus subtypes in oral lesions compared to healthy oral mucosa.

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2012

    Area of Science:

    • Radiochemistry
    • Toxicology
    • Animal Science

    Background:

    • Strontium-90 (90Sr) is a significant radioactive isotope with potential health implications.
    • Understanding its distribution in young mammals is crucial for assessing exposure risks.

    Purpose of the Study:

    • To investigate the temporal distribution patterns of 90Sr in young Wistar rats.
    • To evaluate the uptake and retention of 90Sr in both soft and hard tissues, including teeth and bones.

    Main Methods:

    • Whole body autoradiography was employed to visualize 90Sr distribution.
    • Five littermate Wistar rats were injected intraperitoneally with 90Sr.
    • Rats were analyzed at multiple time points: 15 minutes, 1, 4, 24, and 72 hours post-injection.

    Main Results:

    • 90Sr rapidly distributed to soft tissues, with deposits largely cleared by 4 hours.
    • Significant accumulation of 90Sr occurred in hard tissues (bones and teeth) between 24 and 72 hours.
    • Tooth enamel showed initial high uptake in occlusal/incisal regions, becoming uniform by 72 hours.
    • Dentin exhibited a progressive increase in radioactivity, involving the entire layer by 72 hours.
    • Initial 90Sr uptake was higher in dentin than enamel, particularly in cervical areas, with this difference diminishing over time.

    Conclusions:

    • Teeth and bones demonstrate a strong correlation in 90Sr uptake patterns.
    • Teeth can serve as reliable indicators of the overall 90Sr body burden in young Wistar rats.

    Related Experiment Videos