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Lymphatic Vessels and Lymph Transport01:16

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Related Experiment Video

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Author Spotlight: Magnetic Bead-Based Isolation of Murine Dermal Lymphatic Endothelial Cells
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Lymphatic drainage efficiency: a new parameter of lymphatic function.

Georgia Keramida1, Emma Wroe1, Nicola Winterman1

  • 1Department of Nuclear Medicine, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK.

Acta Radiologica (Stockholm, Sweden : 1987)
|December 9, 2017
PubMed
Summary
This summary is machine-generated.

A new parameter, lymphatic drainage efficiency (LDE), quantifies the second stage of plasma protein transport to lymph nodes. Lower LDE values in unilaterally normal limbs suggest they are not functionally normal, requiring further clinical evaluation.

Keywords:
LymphedemaTc-99 m-nanocolloidlymphoscintigraphyquantification

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Area of Science:

  • Nuclear medicine
  • Lymphatic physiology
  • Medical imaging analysis

Background:

  • Plasma proteins travel to lymph nodes in two stages: peripheral lymphatic uptake and node transport.
  • Current lymphoscintigraphy methods lack a quantitative measure for the second stage of lymphatic transport.

Purpose of the Study:

  • To introduce and define lymphatic drainage efficiency (LDE), a novel parameter quantifying lymphatic transport to lymph nodes.
  • To assess the clinical utility of LDE in evaluating lymphatic function.

Main Methods:

  • 102 patients underwent lymphoscintigraphy with Tc-99m-nanocolloid injection in the foot.
  • Lymphatic drainage efficiency (LDE) was calculated as the ratio of activity in ilio-inguinal nodes at 150 minutes to the activity leaving the injection depot.
  • Abnormal lymphoscintigraphy was defined qualitatively based on tracer uptake, diversion, or focal accumulation.

Main Results:

  • Lymphatic drainage efficiency (LDE) was significantly lower in unilaterally normal limbs compared to bilaterally normal limbs.
  • Lower LDE values were observed in limbs with skin diversion or delayed lymphatic transport.
  • Quantitative analysis revealed that unilaterally normal limbs on lymphoscintigraphy are functionally impaired.

Conclusions:

  • Lymphatic drainage efficiency (LDE) is a promising quantitative index for assessing lymphatic transport.
  • LDE has potential value in clinical research for identifying sub-optimally functioning lymphatic systems.
  • Further clinical evaluation is needed to establish LDE as a standard diagnostic tool.