Related Experiment Video

Updated: Feb 17, 2026

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
04:53

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

1.5K

Outcomes in coronary artery disease patients with sleepy obstructive sleep apnoea on CPAP

Yüksel Peker1,2, Erik Thunström2,3, Helena Glantz4

  • 1Dept of Pulmonary Medicine, Faculty of Medicine, Marmara University, Istanbul, Turkey yuksel.peker@marmara.edu.tr.

The European Respiratory Journal
|December 9, 2017
PubMed

Insights

Coronary artery disease patients with treated obstructive sleep apnea showed no increased risk for major adverse cardiovascular events compared to those without sleep apnea, suggesting CPAP treatment is effective.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Clinical Research

Background:

  • Patients with coronary artery disease (CAD) and obstructive sleep apnea (OSA) face higher risks of major adverse cardiovascular and cerebrovascular events (MACCEs).
  • The impact of continuous positive airway pressure (CPAP) treatment on these risks in OSA patients with CAD is not fully understood.

Purpose of the Study:

  • To determine if the risk of MACCEs is similar between CAD patients with treated OSA and CAD patients without OSA.
  • To evaluate the effectiveness of CPAP therapy in mitigating cardiovascular risks associated with OSA in CAD patients.

Main Methods:

  • An observational study involving revascularised CAD patients with OSA (apnea-hypopnea index ≥15) and daytime sleepiness, offered CPAP treatment (n=155).
  • A control group of CAD patients without OSA (apnea-hypopnea index <5) (n=112) was included.
  • Primary endpoint was the first MACCE event, with a median follow-up of 57 months.

Main Results:

  • The incidence of MACCEs was 23.2% in the OSA group versus 16.1% in the no-OSA group (adjusted hazard ratio 0.96, p=0.923).
  • Age and prior revascularization were associated with increased MACCE risk.
  • Coronary artery bypass grafting at baseline was linked to a reduced risk of MACCEs.

Conclusions:

  • The risk for MACCEs was not significantly increased in CAD patients with symptomatic OSA receiving CPAP treatment compared to those without OSA.
  • CPAP therapy appears to normalize the cardiovascular risk profile in CAD patients with OSA, bringing it closer to that of patients without OSA.

More Related Videos

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

20.7K
Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders05:34

Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders

Published on: August 18, 2023

3.6K

Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
602
Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.6K
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
864
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
416
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
647
Hyperpnea and Hyperventilation01:25

Hyperpnea and Hyperventilation

Hyperventilation refers to a higher-than-normal rate and depth of breathing, often associated with anxiety attacks. This excessive breathing surpasses the body's need to expel CO2, leading to a condition known as hypocapnia - an unusually low level of carbon dioxide in the blood. Hypocapnia can constrict cerebral blood vessels, reducing blood flow to the brain, which may result in dizziness or fainting. Early signs include tingling and muscle spasms in the hands and face, caused by falling...
3.0K