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Updated: Feb 17, 2026
Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases
Published on: December 6, 2016
On the Reproducibility of Inversion Recovery Intravoxel Incoherent Motion Imaging in Cerebrovascular Disease
S M Wong1,2, W H Backes1,2, C E Zhang3,2,4
1From the Departments of Radiology and Nuclear Medicine (S.M.W., W.H.B., C.R.L.P.N.J., J.F.A.J.).
Background And Purpose:
Intravoxel incoherent motion imaging can measure both microvascular and parenchymal abnormalities simultaneously. The contamination of CSF signal can be suppressed using inversion recovery preparation. The clinical feasibility of inversion recovery-intravoxel incoherent motion imaging was investigated in patients with cerebrovascular disease by studying its reproducibility.
Materials And Methods:
Sixteen patients with cerebrovascular disease (66 ± 8 years of age) underwent inversion recovery-intravoxel incoherent motion imaging twice. The reproducibility of the perfusion volume fraction and parenchymal diffusivity was calculated with the coefficient of variation, intraclass correlation coefficient, and the repeatability coefficient. ROIs included the normal-appearing white matter, cortex, deep gray matter, white matter hyperintensities, and vascular lesions.
Results:
Values for the perfusion volume fraction ranged from 2.42 to 3.97 ×10-2 and for parenchymal diffusivity from 7.20 to 9.11 × 10-4 mm2/s, with higher values found in the white matter hyperintensities and vascular lesions. Coefficients of variation were <3.70% in normal-appearing tissue and <9.15% for lesions. Intraclass correlation coefficients were good to excellent, showing values ranging from 0.82 to 0.99 in all ROIs, except the deep gray matter and cortex, with intraclass correlation coefficients of 0.66 and 0.54, respectively. The repeatability coefficients ranged from 0.15 to 0.96 × 10-2 and 0.10 to 0.37 × 10-4 mm2/s for perfusion volume fraction and parenchymal diffusivity, respectively.
Conclusions:
Good reproducibility of inversion recovery-intravoxel incoherent motion imaging was observed with low coefficients of variation and high intraclass correlation coefficients in normal-appearing tissue and lesion areas in cerebrovascular disease. Good reproducibility of inversion recovery-intravoxel incoherent motion imaging in cerebrovascular disease is feasible in monitoring disease progression or treatment responses in the clinic.
Insights
Inversion recovery-intravoxel incoherent motion imaging shows good reproducibility for measuring microvascular and parenchymal changes in cerebrovascular disease. This technique is clinically feasible for monitoring disease progression and treatment response.
Area of Science:
- Neuroimaging
- Medical Physics
- Radiology
Background:
- Intravoxel incoherent motion (IVIM) imaging offers simultaneous measurement of microvascular and parenchymal abnormalities.
- Cerebrospinal fluid (CSF) signal contamination can be mitigated using inversion recovery (IR) preparation.
- Assessing the clinical feasibility of IR-IVIM imaging in cerebrovascular disease (CVD) is crucial.
Purpose of the Study:
- To investigate the clinical feasibility of IR-IVIM imaging in patients with CVD.
- To evaluate the reproducibility of IR-IVIM parameters in various brain tissues and lesions.
- To determine the potential of IR-IVIM for monitoring disease progression and treatment response.
Main Methods:
- Sixteen patients with CVD underwent repeated IR-IVIM imaging sessions.
- Reproducibility of perfusion volume fraction (PVF) and parenchymal diffusivity (D) was assessed using coefficient of variation (CV), intraclass correlation coefficient (ICC), and repeatability coefficient (RC).
- Regions of interest (ROIs) included normal-appearing white matter, cortex, deep gray matter, white matter hyperintensities, and vascular lesions.
Main Results:
- PVF ranged from 2.42-3.97 × 10-2 and D from 7.20-9.11 × 10-4 mm2/s, with higher values in lesions.
- CV was <3.70% in normal tissue and <9.15% in lesions.
- ICC values were good to excellent (0.82–0.99) in most ROIs, except deep gray matter (0.66) and cortex (0.54). RC ranged from 0.15–0.96 × 10-2 for PVF and 0.10–0.37 × 10-4 mm2/s for D.
Conclusions:
- IR-IVIM imaging demonstrated good reproducibility with low CV and high ICC in normal-appearing tissue and lesions in CVD patients.
- The findings suggest that IR-IVIM imaging is clinically feasible for monitoring CVD progression and treatment efficacy.
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