Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.7K
3.7K
Types of RNA01:20

Types of RNA

9.9K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
9.9K
Types of RNA01:23

Types of RNA

73.2K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
73.2K
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

1.4K
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.4K
Formation of Muscle Fibers from Myoblasts01:13

Formation of Muscle Fibers from Myoblasts

6.1K
De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
6.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of angiotensin II and angiotensin II type 1 receptor antagonist on the proliferation, contraction and collagen synthesis in rat hepatic stellate cells.

Chinese medical journal·2008
Same author

[Determination of nicotinamide in formula milk powder using liquid chromatography-isotope dilution mass spectrometry].

Se pu = Chinese journal of chromatography·2008
Same author

In vivo tracking of superparamagnetic iron oxide nanoparticle-labeled mesenchymal stem cell tropism to malignant gliomas using magnetic resonance imaging. Laboratory investigation.

Journal of neurosurgery·2008
Same author

Enhancement and broadening of extreme-ultraviolet supercontinuum in a relative phase controlled two-color laser field.

Optics letters·2008
Same author

Screening and breeding of high taxol producing fungi by genome shuffling.

Science in China. Series C, Life sciences·2008
Same author

Reversible self-association of a concentrated monoclonal antibody solution mediated by Fab-Fab interaction that impacts solution viscosity.

Journal of pharmaceutical sciences·2008

Related Experiment Video

Updated: Feb 17, 2026

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
08:52

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

3.5K

Long noncoding RNAs: a new regulatory code in osteoarthritis.

Xiao Cen1, Xin-Qi Huang2, Wen-Tian Sun2

  • 1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan UniversityChengdu, China.

American Journal of Translational Research
|December 9, 2017
PubMed
Summary

Long noncoding RNAs (lncRNAs) show abnormal expression in osteoarthritis (OA) cartilage. These molecules regulate OA progression by affecting chondrocyte survival, inflammation, and blood vessel growth, offering diagnostic and therapeutic potential.

Keywords:
Long noncoding RNAcartilageosteoarthritis

More Related Videos

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
06:06

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

6.9K
Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells
05:27

Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells

Published on: June 16, 2023

2.4K

Related Experiment Videos

Last Updated: Feb 17, 2026

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
08:52

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

3.5K
Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
06:06

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

6.9K
Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells
05:27

Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells

Published on: June 16, 2023

2.4K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Rheumatology

Background:

  • Osteoarthritis (OA) is characterized by aberrant expression of long noncoding RNAs (lncRNAs) in cartilage.
  • lncRNAs are increasingly recognized as key regulators in OA pathogenesis.
  • These noncoding RNAs interact with various molecular targets, influencing critical OA processes.

Purpose of the Study:

  • To review identified long noncoding RNAs (lncRNAs) in osteoarthritis (OA).
  • To discuss the role of lncRNAs in chondrocyte and synoviocyte survival.
  • To explore the potential of lncRNAs in OA diagnosis, therapy, and prognosis.

Main Methods:

  • Literature review of studies identifying lncRNAs in OA.
  • Analysis of lncRNA functions related to OA pathogenesis.
  • Synthesis of current evidence on lncRNA impact on cellular survival and angiogenesis.

Main Results:

  • Numerous lncRNAs have been identified in OA.
  • lncRNAs influence chondrocyte and synoviocyte survival pathways.
  • lncRNAs modulate arthritis-associated factors and angiogenesis in OA.

Conclusions:

  • lncRNAs are significant players in osteoarthritis.
  • lncRNAs present potential as biomarkers for OA diagnosis and prognosis.
  • Targeting lncRNAs offers a promising therapeutic strategy for OA.