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Updated: Feb 17, 2026

Merging Ion Concentration Polarization between Juxtaposed Ion Exchange Membranes to Block the Propagation of the Polarization Zone
Published on: February 23, 2017
Hyperpolarization of amino acid derivatives in water for biological applications
S Glöggler1, S Wagner2, L-S Bouchard1,3,4
1Department of Chemistry and Biochemistry , University of California at Los Angeles , Los Angeles , California 90095-1569 , USA .
Abstract:
We report on the successful synthesis and hyperpolarization of N-unprotected α-amino acid ethyl propionate esters and extensively, on an alanine derivative hyperpolarized by PHIP (4.4 ± 1.0% 13C-polarization), meeting required levels for in vivo detection. Using water as solvent increases biocompatibility and the absence of N-protection is expected to maintain biological activity.
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