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Updated: Feb 17, 2026
Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
Published on: December 29, 2023
GLUT2-Expressing Neurons as Glucose Sensors in the Brain: Electrophysiological Analysis
Gwenaël Labouèbe1, Bernard Thorens2, Christophe Lamy3
1Center for Integrative Genomics, University of Lausanne, Genopode Building, Lausanne, 1015, Switzerland. Gwenael.Labouebe@unil.ch.
Abstract:
Brain glucose sensing plays an essential role in the regulation of energy homeostasis. Recent publications report that neurons expressing glucose transporter GLUT2 act as glucose sensors in different regions of the brain and contribute to the control of glucose homeostasis and feeding behavior. In this chapter we describe the methods used to explore glucose sensing in genetically tagged GLUT2-expressing neurons with slice electrophysiology.
