Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Emergence of multiply resistant pneumococci.

M R Jacobs, H J Koornhof, R M Robins-Browne

    The New England Journal of Medicine
    |October 5, 1978
    PubMed
    Summary

    Multiple antimicrobial resistance in Streptococcus pneumoniae was found in Johannesburg. Penicillin-resistant strains were prevalent in pediatric patients and hospital staff, necessitating further investigation and screening methods.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evaluation of the GenoType MTBDR<i>sl</i> Version 2.0 Assay for Second-Line Drug Resistance Detection of Mycobacterium tuberculosis Isolates in South Africa.

    Journal of clinical microbiology·2016
    Same author

    Traumatic central cord syndrome: neurological and functional outcome at 3 years.

    Spinal cord·2016
    Same author

    Confocal Scanning Microscopy in Assessment of Cardiac Allograft Rejection--A Pilot Study.

    Transplantation proceedings·2015
    Same author

    Paired pulse depression in the somatosensory cortex: associations between MEG and BOLD fMRI.

    NeuroImage·2011
    Same author

    fMRI and MEG analysis of visceral pain in healthy volunteers.

    Neurogastroenterology and motility·2011
    Same author

    Ontario walk-in clinics: a preliminary descriptive study.

    Canadian family physician Medecin de famille canadien·2011

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Antimicrobial Resistance

    Background:

    • Multiple antimicrobial resistance in Streptococcus pneumoniae (pneumococci) was identified in Johannesburg in July 1977.
    • This discovery prompted an investigation into the prevalence of resistant strains within hospital settings.

    Purpose of the Study:

    • To determine the prevalence of penicillin-resistant pneumococcal strains among pediatric patients and hospital staff in two Johannesburg hospitals.
    • To characterize the antimicrobial resistance patterns of isolated pneumococcal strains.

    Main Methods:

    • A survey was conducted on 543 pediatric patients and 434 hospital staff members.
    • Modified Kirby-Bauer technique and minimum inhibitory concentration measurements were used to screen and confirm penicillin resistance.

    Related Experiment Videos

    Main Results:

    • Penicillin-resistant pneumococci (Types 6A and 19A) were found in 29% of pediatric patients and 2% of hospital staff.
    • Multiply resistant Type 19A strains, resistant to multiple antibiotics including beta-lactams, erythromycin, clindamycin, tetracycline, and chloramphenicol, were isolated from 128 carriers and caused bacteremia in four patients.
    • Other isolates showed resistance to penicillin alone, or in combination with chloramphenicol and/or tetracycline.

    Conclusions:

    • Penicillin-resistant pneumococci, including multiply resistant strains, were prevalent in the studied population in Johannesburg.
    • The findings highlight the need for effective screening methods, such as the modified Kirby-Bauer technique, for detecting penicillin resistance in pneumococci.