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Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Updated: Feb 17, 2026

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Published on: March 1, 2013

Long Circulating Polymeric Nanoparticles for Gene/Drug Delivery.

Jiaming Hu¹, Yan Sheng², Junfeng Shi¹

¹Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210, United States.

Current Drug Metabolism

|December 9, 2017

Summary

Developing long-circulating polymeric nanoparticles is crucial for effective gene/drug delivery. Surface modification strategies, including PEGylation, are key to enhancing nanoparticle circulation time for improved therapeutic outcomes.

Keywords:

Long circulation biodistribution gene/drug delivery mononuclear phagocyte system opsonization polymeric nanoparticles.

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Last Updated: Feb 17, 2026

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Assembly and Characterization of Polyelectrolyte Complex Micelles

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Published on: March 2, 2020

Area of Science:

Nanotechnology
Biomedical Engineering
Materials Science

Background:

Prolonged nanoparticle circulation is essential for targeted gene/drug delivery.
Current methods like PEGylation offer limited circulation times for clinical needs.

Purpose of the Study:

To review recent advances in designing polymeric nanoparticles for extended blood circulation.
To discuss factors influencing nanoparticle surface characteristics and modifications.

Main Methods:

Review of literature on polymeric nanoparticle design and fabrication.
Analysis of surface modification techniques and their impact on circulation time.

Main Results:

Particle size, surface charge, and hydrophilicity significantly influence nanoparticle circulation.
Surface modifications using PEG and polysaccharides are common strategies.
Stimuli-responsive modifications can enhance targeting strategies.

Conclusions:

Novel coating materials are needed to further improve long-circulating polymer-based nanoparticles.
Optimizing nanoparticle properties is critical for successful clinical translation of nanomedicines.