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Primary bilateral uveal melanoma: a population-based study and systematic review
Jeffrey F Scott1, Ritva Vyas1, Jessica Galvin1
1Department of Dermatology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio, USA.
Clinical & Experimental Ophthalmology
|December 9, 2017
Summary
Primary bilateral uveal melanoma (UM) patients have similar characteristics and prognoses to those with unilateral UM. Developing bilateral disease does not worsen outcomes, supporting similar treatment approaches for both conditions.
Area of Science:
- Ophthalmology
- Oncology
- Melanoma Research
Background:
- Primary bilateral uveal melanoma (UM) is a rare condition with limited characterization.
- Comparative data between bilateral and unilateral UM patients are lacking.
Purpose of the Study:
- To comprehensively characterize and compare patients with primary bilateral and unilateral uveal melanoma.
- To determine if bilateral UM affects prognosis compared to unilateral UM.
Main Methods:
- Retrospective, population-based study and systematic literature review.
- Analysis of 52 bilateral UM cases from multiple data sources.
- Comparison with 8915 unilateral UM cases from the SEER-18 database.
Main Results:
- No significant differences were observed in demographics, clinicopathological features, or treatments between bilateral and unilateral UM.
- No differences in overall survival were found between patients with unilateral and bilateral UM.
- Intra-patient comparison of bilateral UM showed no clinicopathological differences between the two eyes.
Conclusions:
- Bilateral and unilateral UM patients share similar characteristics and prognoses.
- The development of bilateral uveal melanoma does not indicate a poorer prognosis.
- Treatment strategies for bilateral UM should align with those for unilateral UM.
