Related Experiment Video
Updated: Feb 17, 2026
An Improved Method for Rapid Intubation of the Trachea in Mice
Published on: February 22, 2016
Physiological effects of brominated flame retardants on NC/Nga mice
Michitaka Tanaka1, Ken-Ichiro Inoue2, Akinori Shimada3
1a Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering , Kyoto University , Kyoto , Japan.
Purpose:
Brominated flame retardants (BFRs) are used as an additive or reactive components in various materials. Regarding their health concerns, their immunotoxicity have not been clarified yet.
Materials And Methods:
In the current study, we examined the effects of systemic exposure to two types of BFRs, DE71 and DE79, on pathophysiologic traits of murine atopic dermatitis (AD). Male NC/Nga mice were repeatedly injected intraperitoneally with DE71 and DE79 and/or mite allergen (Dermatophagoides pteronyssinus: Dp) into their right ears. Thereafter, clinical scores, macroscopic findings of inflammatory foci, and Ig values in serum were examined.
Results:
Both DEs significantly aggravated clinical scores induced by mite allergen including skin dryness and edema. Total IgE titer was significantly greater in the Dp + DE79 group than in the Dp group.
Conclusions:
Taken together, exposure to BFRs can exacerbate AD-like skin lesions related to mite allergen in mice. The accentuating effects may be mediated, at least in part, through hyperproduction of IgE.
