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Modulating secreted components of tumor microenvironment: A masterstroke in tumor therapeutics

Himadri Patel1, Pritish Nilendu1, Devashree Jahagirdar1

  • 1a Cancer and Translational Research Lab, Dr. D.Y. Patil Biotechnology & Bioinformatics Institute, Dr. D.Y. Patil Vidyapeeth , Pune , Maharashtra , India.

Cancer Biology & Therapy
|December 9, 2017
PubMed

Insights

The tumor microenvironment

Area of Science:

  • Oncology
  • Cancer Biology
  • Biochemistry

Background:

  • The tumor microenvironment (TME) significantly influences cancer progression and drug resistance.
  • The TME comprises diverse cellular and non-cellular elements, varying with tumor characteristics.
  • Non-cellular secreted components within the TME are increasingly recognized for their roles.

Purpose of the Study:

  • To review the critical role of non-cellular components in the TME.
  • To highlight their contribution to cancer survival, progression, and therapeutic resistance.
  • To explore their potential in precision therapeutics and biomarker development.

Main Methods:

  • Review of recent pre-clinical evidence.
  • Analysis of clinical trial data.
  • Synthesis of current research on TME non-cellular components.

Main Results:

  • Non-cellular TME components provide metabolites, energy, and growth signals.
  • These components facilitate immune evasion, drug resistance, metastasis, and angiogenesis.
  • Evidence supports their role in supporting cancer survival and progression.

Conclusions:

  • Targeting pro-cancer to anti-cancer activities of secreted TME components offers a novel therapeutic strategy.
  • Non-cellular TME components are crucial for developing precision cancer therapeutics.
  • These components hold significant potential for future biomarker studies in oncology.
Keywords:
Biomarkers ImmunosurveillanceChemotherapyGenomic instabilityHeterogeneityMicroenvironmentTumor

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