Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

6.1K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
6.1K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.9K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.9K
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

4.8K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
4.8K
The Parathyroid Glands00:59

The Parathyroid Glands

5.4K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
5.4K
Bone Remodeling01:40

Bone Remodeling

40.6K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.6K
Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

4.0K
Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hyperprolactinemia.

Postgraduate medicine·2017
Same author

Thyroid function tests.

Postgraduate medicine·2017
Same journal

Clinical pharmacokinetics of colistimethate sodium and formed colistin in patients with renal impairment or on dialysis modalities: a systematic review and implications for precision dosing.

Postgraduate medicine·2026
Same journal

The role of type D personality in pregnancy symptom severity, functional limitations, and maternal ambivalence.

Postgraduate medicine·2026
Same journal

Operational and demographic predictors of leaving without being seen in a high-volume tertiary emergency department: a five-year case-control study.

Postgraduate medicine·2026
Same journal

Risk of adverse effects of the concomitant use of statins with calcium channel blockers: a systematic review and meta-analysis.

Postgraduate medicine·2026
Same journal

Association between frailty and major chronic disease-free life expectancy: a large community-based longitudinal study.

Postgraduate medicine·2026
Same journal

The prevalence of functional iron deficiency and its impact on mortality in patients receiving hemodialysis.

Postgraduate medicine·2026
See all related articles

Related Experiment Video

Updated: Feb 17, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

2.6K

Hypercalcemia.

Todd B Kaye

    Postgraduate Medicine
    |December 9, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Elevated serum calcium requires investigation into causes like hyperparathyroidism, malignancy, or vitamin toxicity. This article reviews clinical evaluation and treatment options to restore normal calcium levels.

    More Related Videos

    Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
    03:57

    Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

    Published on: July 14, 2023

    2.4K
    Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry
    10:24

    Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry

    Published on: October 28, 2014

    15.8K

    Related Experiment Videos

    Last Updated: Feb 17, 2026

    A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
    11:30

    A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

    Published on: June 2, 2022

    2.6K
    Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
    03:57

    Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

    Published on: July 14, 2023

    2.4K
    Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry
    10:24

    Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry

    Published on: October 28, 2014

    15.8K

    Area of Science:

    • Endocrinology
    • Internal Medicine

    Background:

    • Elevated serum calcium (hypercalcemia) is a common clinical finding.
    • Hypercalcemia can result from various underlying conditions, necessitating a systematic diagnostic approach.

    Purpose of the Study:

    • To provide a comprehensive overview of the clinical evaluation of hypercalcemia.
    • To outline current therapeutic strategies for managing hypercalcemia.

    Main Methods:

    • Review of clinical guidelines and literature on hypercalcemia.
    • Discussion of diagnostic workup including laboratory tests and imaging.
    • Overview of pharmacologic and non-pharmacologic treatment modalities.

    Main Results:

    • Differential diagnosis of hypercalcemia includes primary hyperparathyroidism, malignancy-associated hypercalcemia, and vitamin D toxicity.
    • Diagnostic evaluation involves assessing clinical presentation, serum calcium, phosphate, parathyroid hormone levels, and vitamin D levels.
    • Treatment strategies aim to address the underlying cause and restore normocalcemia through hydration, medications (e.g., bisphosphonates), and potentially surgery.

    Conclusions:

    • A thorough investigation is crucial for identifying the cause of hypercalcemia.
    • Management requires a multi-faceted approach tailored to the specific etiology.
    • Effective treatment strategies can successfully restore normal calcium levels and improve patient outcomes.