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Related Experiment Video

Updated: May 3, 2026

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

Published on: February 4, 2013

Programmable self-assembly of three-dimensional nanostructures from 10,000 unique components.

Luvena L Ong^1,2, Nikita Hanikel¹, Omar K Yaghi¹

¹Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02115, USA.

|December 9, 2017

Summary

This study introduces longer DNA bricks for self-assembling large, complex nanostructures without scaffolds. These DNA nanostructures, reaching gigadalton scale, enable precise 3D sculpting and potential applications in various scientific fields.

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Area of Science:

Nanotechnology
Synthetic Biology
Structural Biology

Background:

Nucleic acids like DNA and RNA are utilized for constructing complex nanostructures.
DNA origami, while powerful, faces challenges with scaffold strand length for larger structures.
DNA bricks offer a scaffold-free self-assembly approach for nanostructures.

Purpose of the Study:

To develop a scalable method for creating large-scale DNA nanostructures.
To overcome limitations of previous DNA brick designs for complex assemblies.
To demonstrate the potential of DNA bricks for advanced 3D molecular sculpting.

Main Methods:

Utilized DNA bricks with longer, 13-nucleotide binding domains for self-assembly.
Designed and assembled gigadalton-scale three-dimensional nanostructures.
Created a molecular canvas using DNA bricks for precise 3D sculpting.

Main Results:

Successfully self-assembled 0.1-1-gigadalton DNA nanostructures from tens of thousands of unique components.
Constructed a 0.5-gigadalton cuboid with approximately 30,000 unique DNA bricks.
Demonstrated the creation of complex 3D shapes, including letters and a teddy bear, within a DNA brick-based molecular canvas.

Conclusions:

Longer DNA bricks enable the creation of significantly larger and more complex DNA nanostructures.
This scaffold-free approach offers a scalable alternative to DNA origami for advanced nanotechnology.
The developed molecular canvas opens possibilities for precise 3D molecular design and functional component positioning.