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Related Experiment Video

Updated: Feb 17, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
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Gene Expression, and Fatigue in Puerto Rican Men during Radiotherapy for Prostate Cancer: an Exploratory Study.

Velda J Gonzalez1, Leorey N Saligan2, Brooke L Fridley3

  • 1College of Nursing, University of South Florida, Tampa, FL, United States, UPR/ MDACC Partnership for Excellence in Cancer Research U54 CA096297.

Puerto Rico Health Sciences Journal
|December 9, 2017
PubMed
Summary
This summary is machine-generated.

Fatigue in Puerto Rican men undergoing radiation therapy remained stable. Gene expression analysis revealed significant changes, potentially linked to the SESN3 gene

Keywords:
Cancer related fatigueGene expressionProstate cancerPuerto RicansRadiotherapy

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Area of Science:

  • Oncology
  • Genomics
  • Psychoneuroimmunology

Background:

  • Prostate cancer patients undergoing External Beam Radiation Therapy (EBRT) often experience fatigue.
  • Understanding fatigue trajectories and underlying molecular mechanisms is crucial for supportive care.

Purpose of the Study:

  • To investigate the fatigue experience of Puerto Rican men during EBRT.
  • To analyze gene expression changes from baseline to the midpoint of EBRT.

Main Methods:

  • Prospective study involving 26 Puerto Rican men with non-metastatic prostate cancer.
  • Fatigue assessed using the FACT-fatigue scale at baseline, midpoint, and end of EBRT.
  • Whole blood gene expression analyzed using microarray technology and Ingenuity Pathway analysis.

Main Results:

  • Fatigue scores remained largely unchanged throughout EBRT (mean baseline: 42.38, endpoint: 43.04).
  • 373 genes were differentially expressed between baseline and midpoint (FDR<0.01), with notable pathways including Phospholipase C Signaling and Gαq Signaling.
  • Individual variability in fatigue was observed despite group stability.

Conclusions:

  • Fatigue did not significantly worsen in this cohort of Puerto Rican men during EBRT.
  • Differential gene expression suggests molecular adaptations occurring during treatment.
  • Overexpression of the SESN3 gene may play a role in mitigating fatigue by suppressing oxidative damage.