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Chemoprevention by resveratrol and pterostilbene: Targeting on epigenetic regulation

Pei-Sheng Lee1, Yi-Shiou Chiou1, Chi-Tang Ho2

  • 1Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan.

Biofactors (Oxford, England)
|December 9, 2017
PubMed

Insights

Dietary compounds like resveratrol and pterostilbene can modify gene expression through epigenetic mechanisms. These stilbenoids show potential in preventing diseases by influencing DNA methylation, histone modifications, and microRNAs.

Area of Science:

  • Epigenetics and molecular biology
  • Nutritional science and chemoprevention

Background:

  • Epigenetic mechanisms regulate cellular functions and are implicated in diseases like cancer and metabolic syndrome.
  • Aberrant epigenetic modifications are reversible and influenced by intrinsic and extrinsic factors.
  • Dietary phytochemicals, including stilbenoids, are emerging as potent epigenetic regulators.

Purpose of the Study:

  • To review the influence of resveratrol and pterostilbene on epigenetic mechanisms.
  • To summarize the underlying molecular mechanisms of these stilbenoids as epigenetic modifiers.

Main Methods:

  • Literature review of studies on stilbenoids and epigenetic modifications.
  • Analysis of molecular mechanisms including DNA methylation, histone modification, and microRNA modulation.

Main Results:

  • Resveratrol and pterostilbene exhibit anti-cancer, anti-inflammatory, anti-lipid, and anti-diabetic properties.
  • These stilbenoids act as epigenetic modifiers by altering DNA methylation, histone modifications, and microRNA expression.
  • Evidence suggests stilbenoids can improve cardiovascular health.

Conclusions:

  • Resveratrol and pterostilbene are potent dietary epigenetic regulators.
  • Their influence on epigenetic mechanisms contributes to their chemopreventive and therapeutic effects.
  • Further research into stilbenoids offers potential for disease prevention and treatment strategies.
Keywords:
chemopreventionepigeneticpterostilbeneresveratrol

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