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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
Published on: July 28, 2020
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Local Control of Soft Tissue and Bone Sarcomas
Joseph G Crompton1, Koichi Ogura1, Nicholas M Bernthal1
1Joseph G. Crompton, Nicholas M. Bernthal, and Fritz C. Eilber, University of California Los Angeles, Los Angeles, CA; and Koichi Ogura and Akira Kawai, National Cancer Center Hospital, Tokyo, Japan.
Summary
Soft tissue and bone sarcomas are cancers that can recur locally, causing significant harm. This review covers current therapeutic strategies, including surgery, radiation, and systemic therapy, for managing these challenging mesenchymal malignancies.
Area of Science:
- Oncology
- Surgical Oncology
- Radiation Oncology
Background:
- Soft tissue and bone sarcomas are mesenchymal malignancies with potential for local recurrence.
- Local recurrence of sarcomas can lead to substantial morbidity and mortality.
- Surgery is the primary method for local control, but often requires adjuvant therapies.
Purpose of the Study:
- To review current therapeutic approaches for local control of soft tissue and bone sarcomas.
- To highlight the role of surgery, perioperative radiation, and systemic therapy in sarcoma management.
Main Methods:
- Literature review of current therapeutic strategies for sarcoma local control.
- Synthesis of information on surgical techniques, radiation protocols, and systemic treatments.
- Analysis of adjuvant therapy roles in managing soft tissue and bone sarcomas.
Main Results:
- Surgery is the cornerstone of local control for sarcomas.
- Perioperative radiation therapy is frequently used to reduce local recurrence rates.
- Systemic therapies play a role in managing advanced or recurrent disease.
Conclusions:
- Multimodal treatment approaches are essential for optimal local control of soft tissue and bone sarcomas.
- Integration of surgery, radiation, and systemic therapy improves outcomes.
- Ongoing research aims to refine therapeutic strategies for sarcoma management.
