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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Related Experiment Video

Updated: Feb 17, 2026

Basophil Activation Test for Allergy Diagnosis
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AllerBase: a comprehensive allergen knowledgebase.

Kiran Kadam1, Rajiv Karbhal1, V K Jayaraman2,3

  • 1Bioinformatics Centre.

Database : the Journal of Biological Databases and Curation
|December 9, 2017
PubMed
Summary
This summary is machine-generated.

This study introduces AllerBase, a comprehensive database for allergen information. It aims to centralize and simplify access to crucial data for researchers and clinicians.

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Area of Science:

  • Bioinformatics
  • Immunology
  • Allergy Research

Background:

  • Allergen information is fragmented across various sources.
  • A centralized, curated database is needed for efficient allergy research.

Purpose of the Study:

  • To develop and present AllerBase, a novel database for comprehensive allergen data.
  • To facilitate easier access and analysis of allergen-related information.

Main Methods:

  • Data aggregation from public repositories and literature.
  • Database curation and standardization of allergen information.
  • Development of a user-friendly web interface for data retrieval.

Main Results:

  • AllerBase provides a unified platform for allergen data.
  • Includes information on allergen sources, protein sequences, and clinical relevance.
  • Offers search and browsing functionalities for diverse user needs.

Conclusions:

  • AllerBase serves as a valuable resource for allergy research and clinical practice.
  • A centralized database improves efficiency in understanding and managing allergies.
  • Future updates will expand the scope and utility of AllerBase.