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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

6.2K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Related Experiment Video

Updated: Feb 17, 2026

Isolating Stem Cells from Soft Musculoskeletal Tissues
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Saving Stem Cells after Stress.

Katherine Y King1

  • 1Pediatric Infectious Diseases, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.

Cell Stem Cell
|December 9, 2017
PubMed
Summary

Hematopoietic stem cells (HSCs) regain quiescence through a novel histamine-dependent feedback loop. This mechanism, involving myeloid bone marrow cells, is crucial for restoring HSC balance after inflammatory stress.

Area of Science:

  • Hematology
  • Stem Cell Biology
  • Immunology

Background:

  • Inflammatory signals activate hematopoietic stem cells (HSCs).
  • The mechanisms by which HSCs return to a quiescent state after stress are not fully understood.
  • Understanding HSC quiescence is vital for managing blood disorders, aging, and immune function.

Purpose of the Study:

  • To elucidate the feedback mechanisms that restore quiescence in hematopoietic stem cells after inflammatory activation.
  • To identify key molecular players involved in the resolution of HSC stress response.

Main Methods:

  • Investigated histamine signaling pathways in myeloid bone marrow cells.
  • Analyzed the impact of histamine on myeloid-biased HSC quiescence.
  • Utilized in vivo and in vitro models to study HSC behavior post-inflammation.

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Forward Genetic Approach to Uncover Stress Resistance Genes in Mice — A High-throughput Screen in ES Cells
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Forward Genetic Approach to Uncover Stress Resistance Genes in Mice — A High-throughput Screen in ES Cells

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Related Experiment Videos

Last Updated: Feb 17, 2026

Isolating Stem Cells from Soft Musculoskeletal Tissues
07:49

Isolating Stem Cells from Soft Musculoskeletal Tissues

Published on: July 5, 2010

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A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells
07:14

A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells

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Forward Genetic Approach to Uncover Stress Resistance Genes in Mice — A High-throughput Screen in ES Cells
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Forward Genetic Approach to Uncover Stress Resistance Genes in Mice — A High-throughput Screen in ES Cells

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Main Results:

  • Identified a histamine-dependent feedback mechanism initiated by myeloid bone marrow cells.
  • Demonstrated that this mechanism actively restores quiescence in myeloid-biased HSCs.
  • Showcased the role of histamine in regulating HSC behavior after inflammatory insults.

Conclusions:

  • A novel histamine-mediated pathway restores hematopoietic stem cell quiescence.
  • This finding has significant implications for understanding and treating age-related blood disorders and immune dysregulation.