Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

681
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
681
Schizophrenia01:17

Schizophrenia

1.1K
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
1.1K
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

656
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
656
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

671
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
671
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

2.1K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.1K
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

730
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
730

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating the Impact of Colored Compomer on Oral Hygiene in 5-8-year-old Children and Assessment of Parental Acceptance: A Cohort Study.

International journal of clinical pediatric dentistry·2026
Same author

PPG-basis: A python-based toolbox for fast photoplethysmogram decomposition and reconstruction.

Computer methods and programs in biomedicine·2026
Same author

Characterizing the influence of skin pigmentation on pulse oximetry.

Biophotonics discovery·2026
Same author

Neurotherapeutic promise of egg-derived antioxidants: mental health implications, and future perspectives.

Journal of the science of food and agriculture·2026
Same author

Nicotine Dependence-Induced Withdrawal Syndrome: Mechanistic Insights and Therapeutic Implications.

CNS & neurological disorders drug targets·2026
Same author

Tailoring Sg-CN with Nickel(II) Atrane for Sustainable Photocatalytic Nitrogen Fixation.

ACS applied materials & interfaces·2025

Related Experiment Video

Updated: Feb 17, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

9.5K

Altered resting state functional connectivity in early course schizophrenia.

Aastha Sharma1, Arvind Kumar2, Sadhana Singh3

  • 1Medical Training Initiative (MTI) Training Fellow, Mental Health Hospital Liaison Team, Central and North West London NHS Foundation trust, Milton Keynes, United Kingdom.

Psychiatry Research. Neuroimaging
|December 9, 2017
PubMed
Summary

Early schizophrenia patients show reduced brain connectivity in key networks. This functional hypoconnectivity in networks like the fronto-parietal and default mode may be crucial for understanding schizophrenia.

Keywords:
Auditory networkEarly course schizophreniaMotor networkResting state networksVisual network

More Related Videos

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.8K
Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.7K

Related Experiment Videos

Last Updated: Feb 17, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

9.5K
Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.8K
Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.7K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Schizophrenia pathophysiology is linked to impaired brain connectivity.
  • Previous functional connectivity studies yield inconsistent findings.
  • Early-course schizophrenia presents a unique window for investigation.

Purpose of the Study:

  • To investigate functional connectivity differences in early-course schizophrenia.
  • To compare brain network connectivity between patients and healthy controls.
  • To identify potential neuroimaging biomarkers for schizophrenia.

Main Methods:

  • Resting-state functional magnetic resonance imaging (rsfMRI) was used.
  • A homogenous sample of 34 early schizophrenia patients and 19 healthy controls participated.
  • Data analysis employed FSL software (FMRIB's Software Library).

Main Results:

  • Schizophrenia patients exhibited significantly decreased functional connectivity.
  • Hypoconnectivity was observed in the left fronto-parietal, visual, motor, default mode, and auditory networks.
  • These findings suggest widespread functional network alterations in early schizophrenia.

Conclusions:

  • Early schizophrenia is characterized by significant functional hypoconnectivity across multiple brain networks.
  • Observed hypoconnectivity may be associated with schizophrenia features beyond those studied.
  • Functional connectivity warrants further investigation as a potential biomarker across diverse schizophrenia phenotypes.