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Sleep-Disordered Breathing among Newborns with Myelomeningocele

Renée A Shellhaas1, Payal V Kenia2, Fauziya Hassan1

  • 1Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI; Sleep Disorders Center, University of Michigan, Ann Arbor, MI.

The Journal of Pediatrics
|December 10, 2017
PubMed

Insights

Neonates with myelomeningocele exhibit a significantly higher apnea-hypopnea index, indicating potential sleep-disordered breathing. Early assessment in these infants may be crucial for timely intervention.

Area of Science:

  • Neonatal Medicine
  • Pediatric Neurology
  • Sleep Medicine

Background:

  • Myelomeningocele is a severe congenital condition affecting spinal cord development.
  • Sleep-disordered breathing is a potential complication in infants with complex medical conditions.

Purpose of the Study:

  • To investigate the prevalence of sleep-disordered breathing in neonates with myelomeningocele.
  • To compare respiratory patterns during sleep between neonates with and without myelomeningocele.

Main Methods:

  • Matched cohort study design.
  • Comparison of apnea-hypopnea index (AHI) between neonates with myelomeningocele and age-matched controls.

Main Results:

  • The apnea-hypopnea index was significantly higher in neonates with myelomeningocele (34 ± 22) compared to controls (19 ± 11; P = .021).
  • This suggests a higher likelihood of sleep-disordered breathing in this population.

Conclusions:

  • Newborns with myelomeningocele show a higher incidence of sleep-disordered breathing.
  • Screening for sleep-disordered breathing in neonates with myelomeningocele is recommended to enable early treatment.
  • The long-term neurodevelopmental impact of this association requires further investigation.

Keywords:
central sleep apneaneonatalobstructive sleep apneapolysomnographyspina bifida

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