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Updated: Feb 17, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Tremulane sesquiterpenes from cultures of the basidiomycete Irpex lacteus
Jian-Hai Ding1, Zheng-Hui Li2, Tao Feng2
1Engineering and Technology Research Center of Liupanshan Resources, College of Chemistry and Chemical Engineering, Ningxia Normal University, Guyuan, Ningxia 756000, PR China; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, Hubei 430074, PR China.
Abstract:
Five new tremulane sesquiterpenes, named irlactins F-J (1-5), were isolated from cultures of the basidiomycete Irpex lacteus together with two known analogues (6 and 7). Structures and relative configurations of compounds 1-5 were elucidated by spectroscopic data analysis. Compund 4 exhibited moderate cytotoxicities on HL-60, SMMC-7721, A-549, MCF-7, and SW480 cells with IC50 values of 16.23, 20.40, 25.55, 19.05, and 18.58μM, respectively.
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