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Updated: Feb 17, 2026
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Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest
Published on: August 6, 2015
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Current interpretation of myocardial stunning
Andrea Igoren Guaricci1, Gabriella Bulzis2, Gianluca Pontone3
1Institute of Cardiovascular Disease, Department of Emergency and Organ Transplantation, University Hospital "Policlinico" of Bari, Bari, Italy; Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
Trends in Cardiovascular Medicine
|December 10, 2017
Summary
Myocardial stunning, a temporary heart dysfunction after ischemia, has diverse causes and mechanisms. This review summarizes clinical conditions leading to this heterogeneous cardiac issue.
Area of Science:
- Cardiology
- Physiology
Background:
- Myocardial stunning is a temporary cardiac mechanical dysfunction following ischemia.
- It is a heterogeneous condition with multiple potential triggers and underlying mechanisms.
Purpose of the Study:
- To review and summarize the clinical conditions associated with stunned myocardium.
- To provide an overview of the causes and mechanisms of myocardial stunning.
Main Methods:
- Literature review of clinical conditions causing myocardial stunning.
- Synthesis of information on underlying pathophysiological mechanisms.
Main Results:
- Identified transient coronary occlusion, catecholamines, endothelin, and inflammation as potential causes.
- Highlighted mechanisms including oxyradical hypothesis, calcium overload, and excitation-contraction uncoupling.
Conclusions:
- Myocardial stunning results from various clinical scenarios.
- Understanding these conditions is crucial for managing post-ischemic cardiac dysfunction.
Keywords:
Calcium overloadCatecholaminesCoronary reperfusionMyocardial ischemiaMyocardial stunningOxyradicalsMore Related Videos
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