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Short sleep and risk of proteinuria in 3-year-olds in Japan: a population-based cohort study

Hongyan Chen1, Maki Shinzawa2, Hironobu Tokumasu1

  • 1Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan.

Sleep Medicine
|December 10, 2017
PubMed

Insights

Short sleep duration in toddlers (18 months) is linked to an increased risk of developing proteinuria by age 3. Early sleep interventions may support kidney health in children.

Area of Science:

  • Pediatrics
  • Nephrology
  • Sleep Medicine

Background:

  • Sleep patterns are established in early childhood.
  • Kidney health is crucial for long-term well-being.

Purpose of the Study:

  • To investigate the association between short sleep duration at 18 months of age and the risk of proteinuria at 3 years of age.

Main Methods:

  • Population-based cohort study of 62,623 children in Japan.
  • Sleep duration assessed via parent-reported questionnaires at 18 months.
  • Proteinuria measured by urinalysis at 3 years; multivariable logistic regression used.

Main Results:

  • Short nighttime sleep (≤8 hours) at 18 months was associated with a 1.50 adjusted odds ratio for proteinuria at 3 years (P=0.02).
  • Later bedtimes and earlier wake times also showed a similar, though weaker, association with proteinuria risk.

Conclusions:

  • Short sleep in early childhood is a potential risk factor for proteinuria.
  • Further research into sleep interventions for promoting kidney health in children is recommended.
Abstract

Keywords:
Chronic kidney diseaseEpidemiologyPreschool childrenProteinuriaSleep duration

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