Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anatomy of the Intestines01:23

Anatomy of the Intestines

88.1K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
88.1K
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

1.7K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.7K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.2K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.2K
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

476
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
476
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

1.6K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.6K
Antibiotic Selection00:57

Antibiotic Selection

60.3K
Overview
60.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Vitro Modulation of Murine Tenocyte Behavior by Hyperbaric Oxygen Therapy.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026
Same author

Circadian and Sleep-Related Polygenic Scores in Relation to Lithium Treatment Response in Bipolar Disorder.

Neuropsychobiology·2026
Same author

DNA methylation patterns and epigenetic aging associated with suicide attempts in bipolar disorder.

Journal of affective disorders·2025
Same author

Trends and associated factors of mental health diagnoses in Catalan Primary Care (2010-2019).

European psychiatry : the journal of the Association of European Psychiatrists·2024
Same author

The impact of the EVLP on the lung microbiome and its inflammatory reaction.

Transplant international : official journal of the European Society for Organ Transplantation·2024
Same author

Identifying digital biomarkers of illness activity and treatment response in bipolar disorder with a novel wearable device (TIMEBASE): protocol for a pragmatic observational clinical study.

BJPsych open·2024

Related Experiment Video

Updated: Feb 17, 2026

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
08:33

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Published on: November 17, 2018

14.0K

Gut Microbiome and Antibiotics.

Tadasu Iizumi1, Thomas Battaglia1, Victoria Ruiz1

  • 1Department of Medicine, New York University School of Medicine NYU Langone Health, New York, NY, USA.

Archives of Medical Research
|December 10, 2017
PubMed
Summary

Antibiotics significantly impact the gut microbiome, especially in early life. This review examines antibiotic effects on gut bacteria and consequences of their misuse.

Keywords:
Antibiotic treatmentsAutoimmune diseasesMicrobiomeObesity

More Related Videos

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

31.3K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

10.5K

Related Experiment Videos

Last Updated: Feb 17, 2026

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
08:33

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Published on: November 17, 2018

14.0K
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

31.3K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

10.5K

Area of Science:

  • Microbiology
  • Human Physiology
  • Pharmacology

Background:

  • The human gastrointestinal tract hosts a dense bacterial population, forming the gut microbiome.
  • This microbiome is sensitive to external factors like diet, hygiene, and medications.
  • Early-life gut microbiota development is particularly vulnerable to disruptions.

Purpose of the Study:

  • To review the impact of antibiotic type and dosage on gut microbiota composition.
  • To discuss the consequences of antibiotic use and misuse on the gut microbiome.

Main Methods:

  • Literature review of studies on antibiotic effects on gut microbiota.
  • Analysis of factors influencing microbiome changes due to antibiotics.

Main Results:

  • Antibiotics, varying by type and dose, alter gut microbiota quantity and quality.
  • Disruptions are more pronounced and lasting when occurring during early-life microbiome establishment.
  • Antibiotic misuse can lead to significant, potentially long-term, negative consequences for gut health.

Conclusions:

  • Antibiotic administration requires careful consideration due to its profound effects on the gut microbiome.
  • Understanding these effects is crucial for mitigating risks associated with antibiotic therapy, particularly in vulnerable populations.
  • Further research into microbiome-sparing antibiotics and restoration strategies is warranted.