Related Experiment Video
Updated: Feb 17, 2026
06:11
Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
Published on: February 9, 2022
6.4K
Low Variability in Peak Expiratory Flow Predicts Successful Inhaled Corticosteroid Step-Down in Adults with Asthma
Naomi Tsurikisawa1, Chiyako Oshikata1, Toshio Sato2
1Department of Respirology, National Hospital Organization Saitama National Hospital, Saitama, Japan; Department of Allergy and Respirology, National Hospital Organization Sagamihara National Hospital, Kanagawa, Japan.
The Journal of Allergy and Clinical Immunology. in Practice
|December 10, 2017
Summary
Predicting asthma control after reducing inhaled corticosteroids (ICS) is possible. Key factors include low IL-33, high IL-10, and stable peak expiratory flow (PEF) before dose reduction.
Area of Science:
- Pulmonology
- Allergy and Immunology
Background:
- Prognosis after inhaled corticosteroid (ICS) dose reduction is unclear.
- Predictive factors for maintaining asthma control post-ICS reduction are unknown.
Purpose of the Study:
- Identify predictors for sustained asthma control after a 50% ICS dose reduction.
- Evaluate factors measurable before or during ICS dose adjustment.
Main Methods:
- Prospective study of 223 asthma patients undergoing 50% daily ICS dose reduction.
- Monitored peak expiratory flow (PEF), lung function, bronchial hyperresponsiveness, and inflammatory markers (sputum eosinophils, serum IgE, IL-10, IL-33, TSLP).
Main Results:
- Asthma control was maintained in 59.6% of patients over 36 months.
- Predictive factors for control included low serum IL-33, low weekly PEF variability, childhood asthma onset, and high serum IL-10.
Conclusions:
- Low serum IL-33 and high serum IL-10 levels predict sustained asthma control after ICS reduction.
- Low PEF variability over one week is also a useful predictor for maintaining asthma control.
Related Concept Videos
01:26COPD: Management Using Bronchodilators and Corticosteroids
852
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
852
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
1.6K
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
1.6K
01:23Inhaled Medications
845
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
845
01:30Asthma-IV: Diagnostic and Management
3.2K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.2K
01:24Asthma-III: Symptoms and Complications
3.4K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
3.4K
01:20Asthma: Pathogenesis and Management
1.4K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.4K