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Related Concept Videos

Complement System01:27

Complement System

11.0K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
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Antimicrobial Proteins01:23

Antimicrobial Proteins

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Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
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Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
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Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
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Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
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Antibody Actions01:26

Antibody Actions

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Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
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Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
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Related Experiment Video

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Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
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Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

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Pathogens' toolbox to manipulate human complement.

Francisco J Fernández1, Sara Gómez2, M Cristina Vega2

  • 1Abvance Biotech srl, Ave. Reina Victoria 32, 28003 Madrid, Spain.

Seminars in Cell & Developmental Biology
|December 10, 2017
PubMed
Summary
This summary is machine-generated.

Pathogens evade the complement system, a key defense against infection. Understanding these evasion tactics is crucial for developing new therapies and managing autoimmune diseases. This knowledge is vital as antibiotic resistance grows.

Keywords:
ComplementImmunoevasionInfection biologyPathogensVirulence factors

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Area of Science:

  • Immunology
  • Microbiology
  • Pathogen Biology

Background:

  • The complement system is vital for mammalian defense against pathogens.
  • Pathogens have evolved sophisticated mechanisms to evade complement effector functions.
  • Understanding pathogen evasion strategies is essential for developing effective therapies.

Purpose of the Study:

  • To explore pathogen strategies for evading the complement system.
  • To investigate the link between pathogen encounters and autoimmune/complement dysregulation diseases.
  • To highlight the role of pathogen proteins, including moonlighting proteins, in virulence and infection.

Main Methods:

  • Review of existing literature on complement-pathogen interactions.
  • Analysis of molecular mechanisms of complement evasion by various pathogens.
  • Exploration of the connection between infections and autoimmune diseases.

Main Results:

  • Pathogen evasion of complement is a complex, multi-faceted process.
  • Pathogen encounters can trigger autoimmune and complement dysregulation diseases.
  • Pathogen proteins, including those with moonlighting functions, play critical roles in infection.

Conclusions:

  • Studying complement evasion by pathogens provides insights into infection drivers and complement function.
  • Identifying pathogen evasion mechanisms is crucial for developing novel therapies, especially in the face of antibiotic resistance.
  • Further research into pathogen virulence factors and their roles in immune evasion is warranted.