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Updated: Feb 17, 2026

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
Published on: November 10, 2023
Role of the microenvironment in myeloid malignancies
Marie Goulard1, Christine Dosquet1,2, Dominique Bonnet3
1INSERM, UMRS1131-Paris Diderot University, Saint Louis Hospital, Paris, France.
Abstract:
The bone marrow microenvironment (BMM) regulates the fate of hematopoietic stem cells (HSCs) in homeostatic and pathologic conditions. In myeloid malignancies, new insights into the role of the BMM and its cellular and molecular actors in the progression of the diseases have started to emerge. In this review, we will focus on describing the major players of the HSC niche and the role of the altered niche function in myeloid malignancies, more specifically focusing on the mesenchymal stroma cell compartment.
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