SNF5 as a prognostic factor in skull base chordoma

Area of Science:

• Oncology
• Molecular Biology
• Pathology

Background:

• Skull base chordoma is a rare bone tumor.
• Understanding prognostic factors is crucial for patient management.

Purpose of the Study:

• To characterize SNF5 expression in skull base chordoma.
• To investigate the association between SNF5 expression and patient outcomes.

Main Methods:

• Tissue microarray and immunohistochemistry were used to evaluate SNF5 expression in 48 skull base chordoma samples.
• Kaplan-Meier survival analysis and multivariable Cox regression were employed to assess survival and identify prognostic factors.

Main Results:

• Low SNF5 expression was significantly correlated with shorter overall survival (OS).
• Age over 55, non-gross total resection, and female sex were associated with shorter progression-free survival (PFS) and OS.
• Age, extent of resection, and sex were independent prognostic factors for PFS, while age was an independent prognostic factor for OS.

Conclusions:

• Low SNF5 expression indicates a poor prognosis in skull base chordoma.
• Age, extent of resection, and sex are significant independent prognostic factors for patient survival.