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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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Related Experiment Video

Updated: Feb 17, 2026

Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction
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Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction

Published on: October 6, 2022

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Long non-coding RNA expression in bladder cancer.

Mohammad Taheri1,2, Mir Davood Omrani1,2, Soudeh Ghafouri-Fard3

  • 1Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Biophysical Reviews
|December 10, 2017
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) play crucial roles in bladder cancer development. Specific lncRNAs act as oncogenes or tumor suppressors, offering potential for early detection and prognosis.

Keywords:
Bladder cancerCancer prognosisOncogenesisTumor suppressionlncRNA

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Last Updated: Feb 17, 2026

Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction
06:01

Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction

Published on: October 6, 2022

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • High-throughput sequencing identifies non-coding RNAs, including long non-coding RNAs (lncRNAs), with critical biological and pathological roles.
  • Altered lncRNA expression is implicated in the pathogenesis of various cancers, including bladder cancer.

Purpose of the Study:

  • To review the roles of specific long non-coding RNAs (lncRNAs) in bladder cancer.
  • To explore the potential of lncRNAs for early detection and prognosis in bladder cancer patients.

Main Methods:

  • Review of in vitro and in vivo studies on lncRNA function in bladder cancer.
  • Analysis of lncRNA expression patterns and their correlation with cancer phenotypes and tumor growth.

Main Results:

  • Several lncRNAs, such as NEAT1, PANDAR, and MALAT1, exhibit oncogenic effects in bladder cancer.
  • Other lncRNAs, including MEG3 and BANCR, function as tumor suppressors in bladder cancer.

Conclusions:

  • lncRNAs are significantly involved in bladder cancer oncogenesis and tumor suppression.
  • Identifying specific lncRNA panels could aid in early detection and improve prognosis for bladder cancer patients.