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Association between MTHFR variant and diabetic neuropathy
Armita Kakavand Hamidi1, Mania Radfar2, Mahsa M Amoli1
1Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Pharmacological Reports : PR
|December 10, 2017
Summary
The MTHFR 677 gene variant is linked to an increased risk of diabetic peripheral neuropathy in Iranian type 2 diabetes patients. This finding highlights the role of MTHFR gene variations in diabetes complications.
Area of Science:
- Genetics and Molecular Biology
- Endocrinology
- Neurology
Background:
- Methylene-tetrahydrofolate reductase (MTHFR) gene variants influence homocysteine and peroxynitrite levels, impacting diabetes pathophysiology.
- Diabetic peripheral neuropathy (DPN) is a common complication of diabetes.
- MTHFR gene's role in DPN pathogenesis warrants investigation.
Purpose of the Study:
- To examine the association between MTHFR gene polymorphisms (C677T and 1298A/C) and diabetic neuropathy.
- To determine if MTHFR variants are risk factors for DPN in type 2 diabetes patients.
Main Methods:
- A case-control study involving 248 patients with type 2 diabetes (141 with DPN, 107 without).
- MTHFR C677T polymorphism analyzed via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
- MTHFR 1298A/C polymorphism assessed using Amplification Refractory Mutation System-PCR (ARMS-PCR).
Main Results:
- A significant difference in MTHFR gene polymorphism was observed between patients with and without diabetic neuropathy.
- The MTHFR C677T variant showed a notable association with DPN.
Conclusions:
- The MTHFR 677 variant appears to confer a risk for developing diabetic neuropathy.
- These findings suggest MTHFR gene polymorphisms are relevant to DPN in Iranian type 2 diabetes patients.
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