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Host susceptibility to MERS-CoV infection, a retrospective cohort study of the 2015 Korean MERS outbreak

Jae-Hoon Ko1, Hyeri Seok1, Ga Eun Park1

  • 1Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06531, Republic of Korea.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|December 11, 2017
PubMed

Insights

Individuals who underwent autologous stem cell transplantation or experienced tachypnea (rapid breathing) in the emergency department were more susceptible to Middle East respiratory syndrome coronavirus (MERS-CoV) infection during the 2015 outbreak.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Immunology

Background:

  • The 2015 MERS outbreak in Korea provided a unique opportunity to study host susceptibility factors.
  • Understanding these factors is crucial for preventing future MERS-CoV (Middle East respiratory syndrome coronavirus) transmissions.

Purpose of the Study:

  • To identify host-related risk factors for MERS-CoV infection.
  • To analyze susceptibility among individuals closely exposed to a MERS-CoV super-spreader.

Main Methods:

  • Retrospective cohort study design.
  • Involved 175 individuals with close exposure to a MERS-CoV super-spreader.
  • Multivariate analysis to determine significant risk factors.

Main Results:

  • A total of 26 out of 175 exposed individuals were infected (14.9%).
  • History of autologous stem cell transplantation was a significant risk factor (HR, 31.151; P < 0.001).
  • Tachypnea (rapid breathing) in the emergency department was also significantly associated with MERS-CoV infection (HR, 4.392; P = 0.011).

Conclusions:

  • Autologous stem cell transplantation history and emergency department tachypnea are key indicators of increased MERS-CoV susceptibility.
  • Findings highlight specific patient groups requiring heightened vigilance during MERS-CoV outbreaks.
Keywords:
Middle East respiratory syndrome coronavirusStem cell transplantationSusceptibilityTachypnea

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