The "evolutionary field" hypothesis. Non-Mendelian transgenerational inheritance mediates diversification and...

Area of Science:

• Evolutionary biology
• Epigenetics
• Molecular biology

Background:

• Epigenetics is emerging as a key factor in evolution.
• Regulatory RNAs play crucial roles in cellular information transfer.

Purpose of the Study:

• To propose a novel model for epigenetic inheritance via RNA-mediated intercellular communication.
• To explore the potential of this mechanism in driving evolutionary change.

Main Methods:

• The study proposes a theoretical model based on existing research.
• It integrates concepts of RNA nanovesicles, sperm uptake, fertilization, and reverse transcriptase activity.
• The model speculates on cumulative effects across generations.

Main Results:

• Somatic cells release RNA-containing nanovesicles into the bloodstream.
• These vesicles can cross the Weismann barrier and be taken up by spermatozoa.
• Sperm-delivered RNAs, amplified by reverse transcriptase, may reshape the embryonic epigenome, potentially driving evolutionary novelty.

Conclusions:

• This RNA-mediated mechanism could establish an 'evolutionary field'.
• It offers a platform for generating acquired variations and redirecting evolutionary trajectories.
• The process provides a source of discontinuous evolutionary novelty.