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A novel low molecular weight Enteromorpha polysaccharide-iron (III) complex and its effect on rats with iron
Jiefen Cui1, Yinping Li1, Peng Yu1
1College of Food Science and Engineering, Ocean University of China, Qingdao 266003, PR China.
Abstract:
Iron deficiency anemia (IDA) is a common nutritional disease that affects normal erythropoiesis. Traditional iron supplements usually cause gastrointestinal irritation. In this study, a novel low-molecular-weight polysaccharide from Enteromorpha prolifera (LPE) was prepared by oxidation degradation, and LPE-iron (III) complex was synthesized and characterized. The molecular weight of LPE-iron (III) complex was 21.25kDa, and iron content was 25%. The therapeutic effects of LPE-iron (III) complex on IDA were investigated in rats. The hematological indices and organ coefficients of the rats were analyzed. Results showed a dose-dependent relationship, and a prior intragastric administration of LPE-iron (III) complex (2mg Fe/kg body weight) exhibited considerable effect when compared with the positive control. Therefore, LPE-iron (III) complex could be exploited as a new iron fortifier.
