Related Experiment Video

Updated: Feb 17, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
10:21

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

10.5K

Myeloid Growth Factors, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology

Jeffrey Crawford, Pamela Sue Becker, James O Armitage

    Journal of the National Comprehensive Cancer Network : JNCCN
    |December 11, 2017
    PubMed

    Insights

    Myeloid growth factors (MGFs) help prevent neutropenia in chemotherapy patients. Guidelines focus on risk factors, prophylactic MGF use, and balancing MGF benefits against risks for febrile neutropenia prevention.

    Area of Science:

    • Oncology
    • Hematology
    • Pharmacology

    Background:

    • Myeloid growth factors (MGFs) are crucial supportive care during myelosuppressive chemotherapy.
    • Neutropenia, a common side effect, increases infection risk.
    • Febrile neutropenia (FN) is a serious complication requiring careful management.

    Purpose of the Study:

    • To outline the evaluation of risk factors for chemotherapy-induced febrile neutropenia (FN).
    • To provide guidance on the prophylactic use of MGFs for FN prevention.
    • To assess the overall risks and benefits of MGF utilization in clinical practice.

    Main Methods:

    • Review of NCCN Guidelines for Myeloid Growth Factors.
    • Analysis of regimen- and patient-specific risk factors for FN development.
    • Evaluation of evidence supporting prophylactic MGF use.

    Main Results:

    • Identified key risk factors influencing FN incidence.
    • Established criteria for prophylactic MGF administration.
    • Summarized the risk-benefit profile of MGFs in chemotherapy settings.

    Conclusions:

    • Prophylactic MGF use is recommended based on identified risk factors.
    • Careful assessment of MGF risks and benefits is essential for optimal patient care.
    • Adherence to guidelines ensures effective neutropenia management.

    More Related Videos

    Author Spotlight: Assessing the Potential of Circulating Tumor Cells in Leptomeningeal Disease Research06:25

    Author Spotlight: Assessing the Potential of Circulating Tumor Cells in Leptomeningeal Disease Research

    Published on: March 29, 2024

    1.6K
    Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation12:05

    Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

    Published on: November 3, 2018

    12.4K

    Related Concept Videos

    Differentiation of Common Myeloid Progenitor Cells01:15

    Differentiation of Common Myeloid Progenitor Cells

    Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
    4.1K
    Role of Hematopoietic Growth Factors01:28

    Role of Hematopoietic Growth Factors

    Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
    Thrombopoietin (TPO), mainly released by the liver,...
    4.0K
    Regulation of Hematopoietic Stem Cells01:01

    Regulation of Hematopoietic Stem Cells

    All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
    4.1K
    Mitogens and the Cell Cycle02:38

    Mitogens and the Cell Cycle

    Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
    8.2K
    Abnormal Proliferation02:23

    Abnormal Proliferation

    Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
    5.3K
    Standards of Care II01:19

    Standards of Care II

    Nurses bear specific legal responsibilities under several federal statutes, including:
    1.1K