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Spontaneous cervical artery dissection is accompanied by a hypercoagulable state and simultaneous inflammatory
Johann Otto Pelz1, Kristian Harms2, Michael Metze3
1Department of Neurology, University of Leipzig, Leipzig, Germany. johann.pelz@medizin.uni-leipzig.de.
Journal of Neurology
|December 11, 2017
Summary
Spontaneous cervical artery dissections (sCAD) are linked to a hypercoagulable state, indicated by a shortened activated partial thromboplastin time (aPTT). This suggests inflammation critically impacts sCAD occurrence and involves the coagulation system.
Area of Science:
- Neurology
- Vascular Biology
- Inflammation Research
Background:
- Spontaneous cervical artery dissections (sCAD) are frequently preceded by infections.
- Inflammatory markers in sCAD patients show inconsistent data.
- The role of the coagulation system in sCAD remains under-explored.
Purpose of the Study:
- To investigate the association between inflammatory and coagulation parameters in sCAD patients.
- To explore the link between inflammation and hypercoagulability in sCAD.
Main Methods:
- Retrospective analysis of hospital records from 60 sCAD patients and 97 controls.
- Measured parameters included leukocyte and thrombocyte counts, C-reactive protein, fibrinogen, D-dimer, aPTT, and prothrombin time.
- Univariate and multiple regression analyses were performed.
Main Results:
- sCAD patients exhibited increased leukocyte and thrombocyte counts, and a shortened aPTT compared to controls.
- D-dimer values were decreased in sCAD patients.
- After adjusting for confounders, only the shortened aPTT remained statistically significant (p=0.045).
Conclusions:
- A hypercoagulable state, evidenced by shortened aPTT, is associated with sCAD.
- Findings support the hypothesis that inflammation critically influences sCAD occurrence.
- The study links sCAD to significant alterations in the coagulation system.
Keywords:
CRPCoagulationD-dimerInflammationLeucocyte countShortened aPTTSpontaneous cervical artery dissectionStrokeMore Related Videos
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