Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Drug Reactions01:27

Allergic Drug Reactions

1.5K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.5K
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

16
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
16
Drug Toxicity: Overview01:00

Drug Toxicity: Overview

18
Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
18
Pharmacovigilance01:19

Pharmacovigilance

1.8K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
1.8K
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

18
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
18
Drug toxicity: Idiosyncratic Reactions01:16

Drug toxicity: Idiosyncratic Reactions

21
Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
21

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Long Road of Long COVID: Specific Considerations for the Allergist/Immunologist.

The journal of allergy and clinical immunology. In practice·2023
Same author

A concept for integrated care pathways for atopic dermatitis-A GA<sup>2</sup> LEN ADCARE initiative.

Clinical and translational allergy·2023
Same author

Evaluation of patient-reported outcome measures for on-demand treatment of hereditary angioedema attacks and design of KONFIDENT, a phase 3 trial of sebetralstat.

Clinical and translational allergy·2023
Same author

Clinical severity classes in COVID-19 pneumonia have distinct immunological profiles, facilitating risk stratification by machine learning.

Frontiers in immunology·2023
Same author

Efficacy of Biologics in Patients with Allergic Severe Asthma, Overall and by Blood Eosinophil Count: A Literature Review.

Advances in therapy·2023
Same author

An updated review of pediatric autoimmune neuropsychiatric disorders associated with Streptococcus/pediatric acute-onset neuropsychiatric syndrome, also known as idiopathic autoimmune encephalitis: What the allergist should know.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2023

Related Experiment Video

Updated: Feb 17, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
08:38

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

17.5K

Nonimmunologic adverse drug reactions.

Jonathan A Bernstein

    Postgraduate Medicine
    |December 12, 2017
    PubMed
    Summary

    Minimize adverse drug reactions and costs by understanding predictable and unpredictable drug responses. This system classifies adverse drug reactions for better patient care in primary settings.

    Area of Science:

    • Pharmacology and Clinical Medicine

    Background:

    • Adverse drug reactions (ADRs) contribute significantly to morbidity, mortality, and healthcare costs.
    • Primary care settings frequently encounter predictable ADRs, necessitating awareness.
    • Unpredictable ADRs in susceptible patients pose a clinical challenge.

    Purpose of the Study:

    • To outline a systematic approach for classifying adverse drug reactions.
    • To provide guidance on reducing morbidity and mortality associated with ADRs.
    • To minimize the economic burden of ADRs.

    Main Methods:

    • Review and synthesis of existing literature on ADR classification.
    • Development of a novel system for categorizing ADRs based on predictability and clinical presentation.
    • Analysis of common ADRs encountered in primary care.

    More Related Videos

    Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay
    07:52

    Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

    Published on: September 10, 2018

    9.3K
    Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
    03:40

    Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

    Published on: December 20, 2024

    1.5K

    Related Experiment Videos

    Last Updated: Feb 17, 2026

    Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
    08:38

    Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

    Published on: November 8, 2015

    17.5K
    Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay
    07:52

    Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

    Published on: September 10, 2018

    9.3K
    Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
    03:40

    Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

    Published on: December 20, 2024

    1.5K

    Main Results:

    • A comprehensive system for classifying adverse drug reactions is presented.
    • Identification of key predictable ADRs relevant to primary care practice.
    • Guidance on recognizing and managing unpredictable ADRs in vulnerable patient populations.

    Conclusions:

    • Effective classification of ADRs is crucial for reducing patient harm and healthcare expenditure.
    • Implementing a structured approach to ADR management can improve patient safety.
    • Enhanced understanding of predictable and unpredictable ADRs benefits primary care providers.