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Diagnostic and prognostic tests in systemic lupus erythematosus
Natalia Vasquez-Canizares1, Dawn Wahezi1, Chaim Putterman2
1Division of Pediatric Rheumatology, Children's Hospital at Montefiore and Albert Einstein College of Medicine, Bronx, NY, USA.
Best Practice & Research. Clinical Rheumatology
|December 12, 2017
Summary
Advancements in "omics" technologies offer new hope for diagnosing and monitoring Systemic Lupus Erythematosus (SLE), an autoimmune disease. These high-throughput approaches improve understanding of lupus, aiding patient prognosis.
Area of Science:
- Immunology
- Genomics
- Biomarker Discovery
Background:
- Systemic lupus erythematosus (SLE) is a complex autoimmune disease with varied clinical presentations.
- Diagnosing and monitoring SLE is challenging due to its heterogeneity and lack of specific biomarkers.
- Autoantibodies against self-nuclear antigens are characteristic of SLE.
Purpose of the Study:
- To review recent advancements in biomarker discovery for SLE.
- To highlight the role of "omics" technologies in understanding SLE.
- To discuss the application of novel technologies in SLE diagnosis and prognosis.
Main Methods:
- Review of literature on "omics"-based biomarker discovery in SLE.
- Analysis of high-throughput approaches in the context of SLE research.
- Focus on advancements driven by human genome sequencing.
Main Results:
- "Omics" era technologies provide deeper insights into SLE etiopathogenesis.
- Novel biomarkers are emerging for improved SLE diagnosis and monitoring.
- High-throughput approaches facilitate personalized medicine in SLE.
Conclusions:
- "Omics" technologies are revolutionizing biomarker discovery for SLE.
- These advancements hold significant promise for improving patient outcomes.
- Continued research in this area is crucial for effective SLE management.
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