Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

5.3K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.3K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

6.4K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Upadacitinib enhances platelet procoagulant responses in a subset of healthy individuals and patients with SLE: a pilot study.

Lupus science & medicine·2026
Same author

Machine Learning-Enhanced Autoantibody Discovery and Diagnostics in Systemic Autoimmune Rheumatic Diseases.

Rheumatic diseases clinics of North America·2026
Same author

Effectiveness of a Provincial Law to Improve Epinephrine Use for Anaphylaxis in Schools in Alberta, Canada: A Pre-Post Study.

International archives of allergy and immunology·2026
Same author

Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?

Arthritis care & research·2026
Same author

International expert consensus recommendations on standardised nomenclature of SSA/Ro (TROVE2/Ro60 and TRIM21/Ro52) autoantibodies in autoimmune diseases.

Annals of the rheumatic diseases·2026
Same author

Increased Risk of Intrahepatic Cholestasis of Pregnancy in Women With Systemic Lupus Erythematosus Exposed to Azathioprine.

Arthritis & rheumatology (Hoboken, N.J.)·2026

Related Experiment Video

Updated: Feb 17, 2026

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
07:13

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Published on: April 18, 2025

768

A review on SLE and malignancy.

May Y Choi1, Kelsey Flood2, Sasha Bernatsky3

  • 1Division of Rheumatology, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr NW, Calgary, T2N 4N1, Alberta, Canada.

Best Practice & Research. Clinical Rheumatology
|December 12, 2017
PubMed
Summary
This summary is machine-generated.

Systemic lupus erythematosus (SLE) patients face a higher risk of malignancy due to immune dysregulation and treatments. This review explores cancer risks, contributing factors, and screening guidelines for SLE patients.

Keywords:
AdultAutoimmune diseaseMalignancyPediatricSLE

More Related Videos

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

12.4K

Related Experiment Videos

Last Updated: Feb 17, 2026

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
07:13

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Published on: April 18, 2025

768
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

12.4K

Area of Science:

  • Rheumatology
  • Oncology
  • Immunology

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease predominantly affecting women.
  • Malignancy is a significant cause of mortality in SLE patients, alongside renal injury, cardiovascular disease, and infection.
  • SLE patients exhibit an increased overall risk of malignancy.

Purpose of the Study:

  • To review the association between SLE and malignancy.
  • To evaluate the risk factors and potential mechanisms linking SLE and cancer.
  • To discuss current guidelines for cancer screening and HPV vaccination in SLE.

Main Methods:

  • Review of existing literature on SLE and malignancy.
  • Analysis of overall and site-specific cancer risks in adult and pediatric SLE.
  • Evaluation of risk factors including immunosuppressant drugs, autoantibodies, immune dysregulation, environmental factors, and genetics.

Main Results:

  • Patients with SLE have a slightly elevated overall risk of malignancy.
  • The risk is influenced by disease pathogenesis, immunosuppressant drug use, autoantibodies, immune dysregulation, environmental factors, and genetic susceptibility.
  • Specific cancer risks vary between adult- and pediatric-onset SLE.

Conclusions:

  • The link between SLE and malignancy is multifactorial, involving immune pathways and therapeutic interventions.
  • Understanding these risks is crucial for managing SLE and implementing appropriate cancer screening.
  • Guidelines for cancer screening and HPV vaccination are essential for this patient population.