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K-space trajectories in 3D-GRASE sequence for high resolution structural imaging.

Alexandra Cristobal-Huerta1, Dirk H J Poot2, Mika W Vogel3

  • 1Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

Magnetic Resonance Imaging
|December 12, 2017
PubMed
Summary

New k-space trajectories for 3D-GRASE MRI significantly reduce scan time and specific absorption rates compared to 3D-FSE/TSE. Optimal trajectories enhance 3D-GRASE for high-resolution structural imaging.

Keywords:
Echo planar imaging (EPI)Fast spin echo (FSE)Gradient and spin echo (GRASE)Parallel imagingSARTrajectory

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Biomedical Engineering
  • Radiology

Background:

  • 3D Fast Spin Echo (FSE) / Turbo Spin Echo (TSE) sequences are standard for high-resolution structural MRI.
  • Reducing scan time and specific absorption rate (SAR) are critical challenges in MRI.
  • 3D-Gradient Recalled Echo (GRASE) offers potential for faster acquisition but requires optimized k-space trajectories.

Purpose of the Study:

  • To develop and assess novel k-space trajectories for 3D-GRASE.
  • To improve scan efficiency (reduce scan time) compared to conventional 3D-FSE/TSE.
  • To maintain or enhance image quality for high-resolution structural MRI.

Main Methods:

  • Five novel Cartesian k-space trajectories were designed for 3D-GRASE, incorporating elements from 3D-FSE/TSE.
  • T2 and T2* contrast modulation and autocalibration regions were integrated.
  • Phase modulation artifacts were corrected during reconstruction.
  • Simulations and in-vivo experiments on a 3T scanner were performed.

Main Results:

  • Two proposed 3D-GRASE k-space trajectories yielded image quality comparable to 3D-FSE.
  • Acquisition times were reduced by 27% (PD) and 20% (T2).
  • Specific absorption rates were lowered by 41% (PD) and 75% (T2).

Conclusions:

  • The choice of k-space trajectory is crucial for 3D-GRASE performance.
  • Optimized 3D-GRASE trajectories can offer a superior alternative to 3D-FSE/TSE for high-resolution structural MRI.
  • This approach enables faster and safer MRI scans.