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Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
Published on: February 17, 2017
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Tailoring Trehalose for Biomedical and Biotechnological Applications
Mara K O'Neill1, Brent F Piligian1, Claire D Olson1
1Department of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, MI 48859, USA.
Pure and Applied Chemistry. Chimie Pure Et Appliquee
|December 12, 2017
Summary
Trehalose analogues offer new biomedical and biotechnological applications. Novel synthetic methods enable the development of these compounds for biopreservation and combating pathogens like Mycobacterium tuberculosis.
Area of Science:
- Carbohydrate Chemistry
- Biotechnology
- Medicinal Chemistry
Background:
- Trehalose is a biomolecule-stabilizing sugar crucial in pathogen metabolism, notably Mycobacterium tuberculosis.
- Trehalose is absent in mammals, presenting a target for therapeutic intervention.
- Interest is growing in trehalose analogues for biomedical research and biotechnology.
Purpose of the Study:
- To review novel synthetic methods for trehalose analogue preparation.
- To discuss the development and applications of functionalized trehalose analogues.
- To highlight the potential of trehalose analogues in understanding and treating mycobacterial infections.
Main Methods:
- Chemical synthesis of trehalose analogues.
- Chemoenzymatic synthesis of trehalose analogues.
- Evaluation of synthetic methods for scalability.
Main Results:
- Advancements in chemical and chemoenzymatic routes provide access to diverse trehalose analogues.
- Development of trehalose-based imaging probes and inhibitors for research.
- Exploration of non-degradable trehalose analogues for bioprotection and food applications.
Conclusions:
- Novel synthetic strategies are key to unlocking the potential of trehalose analogues.
- Trehalose analogues show promise as diagnostic and therapeutic agents against Mycobacterium tuberculosis.
- Further development of these analogues could lead to significant advancements in biopreservation and disease treatment.
