Related Experiment Video
Updated: Feb 17, 2026

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
Published on: October 22, 2014
Incidence of Peripheral Arterial Disease and Its Association with Pulse Pressure: A Prospective Cohort Study
Yong Mao1, Yixiang Huang2, Haining Yu3
1Department of Epidemiology and Health Statistics, School of Public Health, Kunming Medical University, Kunming, China.
Background:
The association of pulse pressure and peripheral arterial disease (PAD) has seldom been examined using a prospective design. This study aimed to investigate the association of pulse pressure with PAD incidence in an elderly general population.
Methods:
We utilized data from a cohort conducted in Beijing with additionally 2-year follow-up time. PAD was defined as an ankle brachial index value <0.9 in either leg. Cox proportional hazard regression model was used to quantify the magnitude of pulse pressure on PAD incidence.
Results:
During a 2-year follow-up time, 357 of 4,201 (8.5%) participants developed PAD with 105 (6.9%) men and 252 (9.4%) women, respectively. After adjusting for baseline age, sex, body mass index, hypertension, diabetes, total cholesterol, and high-density lipoprotein cholesterol, and smoking, the hazard ratio and 95% confidence interval for people with pulse pressure greater than 60 mmHg was 2.20 (1.53, 3.15) compared with those whose pulse pressure was less than 40 mmHg. A linear trend was observed for the association of pulse pressure with PAD.
Conclusion:
Higher pulse pressure was associated with higher PAD incidence.
Related Concept Videos
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Pulse
The pulse serves as a clinical...
Peripheral Artery Disease I: Introduction
Peripheral Artery Disease IV: Nursing Management
Sites for measuring blood pressure
The Brachial Artery: Primary Site for Blood Pressure Measurement
Blood Pressure

