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Noncoding RNA and Cardiomyocyte Proliferation

Shuang Qu1, Chunyu Zeng1, Wei Eric Wang1

  • 1Department of Cardiology, Chongqing Institute of Cardiology & Chongqing Cardiovascular Clinical Research Center, Daping Hospital, Third Military Medical University, Chongqing 400042, China.

Stem Cells International
|December 12, 2017
PubMed

Insights

Stimulating cardiomyocyte proliferation is key for cardiac regeneration. This review highlights how noncoding RNAs, especially microRNAs, regulate cardiomyocyte proliferation and offers potential therapeutic targets for heart repair.

Area of Science:

  • Cardiovascular Biology
  • Molecular Biology
  • Regenerative Medicine

Background:

  • Postnatal mammalian cardiomyocytes (CMs) exhibit limited turnover, hindering cardiac repair.
  • Newly formed CMs originate from pre-existing ones, emphasizing the need to stimulate CM proliferation for regeneration.
  • Noncoding RNAs show differential expression in CMs with varying proliferative capacities.

Purpose of the Study:

  • To review the regulatory roles of noncoding RNAs in cardiomyocyte proliferation.
  • To explore the potential of manipulating noncoding RNAs for cardiac regeneration strategies.

Main Methods:

  • Literature review of studies investigating noncoding RNAs and cardiomyocyte proliferation.
  • Analysis of research on microRNA manipulation impacting CM proliferation.
  • Synthesis of findings on the mechanisms underlying noncoding RNA-mediated CM regulation.

Main Results:

  • Noncoding RNAs are differentially expressed in CMs based on proliferation potential.
  • MicroRNA manipulation can either promote or inhibit cardiomyocyte proliferation.
  • Noncoding RNAs are integral to the molecular mechanisms governing CM proliferation.

Conclusions:

  • Noncoding RNAs are critical regulators of cardiomyocyte proliferation.
  • Targeting noncoding RNAs presents a promising avenue for enhancing cardiac regeneration.
  • Understanding these regulatory roles is essential for developing novel therapeutic strategies for heart disease.

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