Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

212
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
212
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

257
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
257
Rh Blood Group01:19

Rh Blood Group

3.5K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
3.5K
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

1.2K
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
1.2K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.8K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.8K
Teratogenicity01:07

Teratogenicity

4.3K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

C3d Complement Activation and Antibody Immunity in Convalescent COVID-19: Insights From Adults and Children.

Journal of immunology research·2026
Same author

Hospital-based vaccination of older adult inpatients: comparison of two delivery models for influenza, COVID-19 and pneumococcal vaccines.

BMC infectious diseases·2026
Same author

When confusion abounds: guideline adherence in the investigation and management of encephalitis in Sydney, Australia.

Internal medicine journal·2026
Same author

Concordance between ICD-10-AM clinical coding and SARS-CoV-2 PCR testing for COVID-19 in Australian hospitals.

Health information management : journal of the Health Information Management Association of Australia·2025
Same author

Gonococcal osteomyelitis and Kirschner-wire infection of the hand.

IDCases·2025
Same author

Remote patient monitoring for managing acute COVID-19, and mortality and hospital use in Sydney, New South Wales, 2021-22: a retrospective observational cohort study.

The Medical journal of Australia·2025

Related Experiment Video

Updated: Feb 17, 2026

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons
09:11

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons

Published on: August 23, 2016

21.4K

Update on hepatitis C and implications for pregnancy.

Jeffrey J Post1

  • 1Department of Infectious Diseases, Prince of Wales Hospital, Sydney, Australia; Prince of Wales Clinical School, UNSW, Sydney, Australia.

Obstetric Medicine
|December 12, 2017
PubMed
Summary

Treating hepatitis C virus infection before pregnancy with direct-acting antivirals nearly eliminates mother-to-child transmission risk. While pregnancy poses risks, delivery mode and breastfeeding are generally safe, but antiviral safety in pregnancy is unknown.

Keywords:
Hepatitis Cantiviral therapymother-to-child transmissionpregnancy

More Related Videos

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

24.7K
A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

10.3K

Related Experiment Videos

Last Updated: Feb 17, 2026

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons
09:11

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons

Published on: August 23, 2016

21.4K
A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

24.7K
A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

10.3K

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Maternal-Fetal Medicine

Background:

  • Hepatitis C virus (HCV) infection can transmit from mother to child.
  • HCV infection in pregnant women is associated with adverse pregnancy and perinatal outcomes.
  • The exact contribution of HCV to these outcomes requires further investigation.

Purpose of the Study:

  • To evaluate the efficacy of pre-pregnancy treatment for hepatitis C virus infection in preventing mother-to-child transmission.
  • To review the risks associated with hepatitis C virus infection during pregnancy and childbirth.
  • To assess the safety of breastfeeding and current antiviral treatments in the context of pregnancy.

Main Methods:

  • Review of existing literature on hepatitis C virus transmission, pregnancy outcomes, and treatment.
  • Analysis of data regarding the impact of direct-acting antivirals (DAAs) on HCV clearance prior to conception.
  • Evaluation of recommendations for delivery practices and infant feeding.

Main Results:

  • Pre-pregnancy treatment of hepatitis C virus infection with direct-acting antivirals effectively eliminates transmission risk in most cases.
  • Adverse pregnancy and perinatal outcomes are more common in women with HCV, though direct causation is complex.
  • Standard delivery practices are not associated with increased HCV transmission; avoidance of invasive procedures is advised.
  • Breastfeeding is not a confirmed risk factor for HCV transmission, with exceptions for cracked or bleeding nipples.
  • The safety of current HCV antivirals during pregnancy and breastfeeding remains undetermined.

Conclusions:

  • Pre-conception cure of hepatitis C virus infection is the most effective strategy to prevent mother-to-child transmission.
  • Management during pregnancy should focus on avoiding invasive procedures, while breastfeeding is generally permissible.
  • Further research is crucial to establish the safety of hepatitis C virus antivirals for use during pregnancy and lactation.