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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Recent advances in radiation oncology.

Cristina Garibaldi1, Barbara Alicja Jereczek-Fossa2,3, Giulia Marvaso2

  • 1Unit of Medical Physics, European Institute of Oncology, 20141 Milan, Italy.

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|December 12, 2017
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Summary

Recent advancements in radiation oncology (RT) utilize technology and biology for precise cancer treatment. Techniques like intensity-modulated RT and adaptive RT improve dose delivery and spare healthy tissues.

Keywords:
adaptive radiotherapyimage guided radiotherapyintensity-modulated radiotherapyradiogenomicsstereotactic body radiotherapy

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Area of Science:

  • Radiation Oncology
  • Medical Physics
  • Cancer Treatment

Background:

  • Radiotherapy (RT) is a cornerstone of cancer management, evolving significantly due to technological progress.
  • Modern RT relies heavily on engineering and computing advancements for improved treatment delivery.

Purpose of the Study:

  • To review recent technological and biological developments in radiation oncology.
  • To highlight state-of-the-art RT techniques and their impact on treatment precision and normal tissue sparing.

Main Methods:

  • Discussion of advanced photon beam techniques: intensity-modulated RT, volumetric-modulated arc therapy, stereotactic body RT, and adaptive RT.
  • Analysis of the RT treatment process, emphasizing imaging, target delineation, planning, and image-guidance.
  • Review of particle beam therapy, including protons and carbon ions.
  • Exploration of biological advances in tumor targeting and personalized treatment strategies.

Main Results:

  • Advanced RT techniques enable highly tailored dose distributions, maximizing tumor control while minimizing damage to surrounding healthy tissues.
  • Multimodality imaging is crucial for adaptive RT, integrating morphological, functional, and metabolic data for precise target identification and treatment monitoring.
  • Real-time imaging is essential for motion management in adaptive RT, particularly for respiratory compensation.

Conclusions:

  • Technological innovations in RT, coupled with radiobiological insights, are enhancing treatment effectiveness and enabling personalized cancer care.
  • The integration of advanced imaging and sophisticated planning/delivery techniques represents the forefront of radiation oncology.