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Operant Procedures for Assessing Behavioral Flexibility in Rats
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Ranges of phenotypic flexibility in healthy subjects.

T J van den Broek1, G C M Bakker1, C M Rubingh1

  • 1TNO, Utrechtseweg 48, 3704 HE Zeist, The Netherlands.

Genes & Nutrition
|December 12, 2017
PubMed
Summary
This summary is machine-generated.

The PhenFlex test (PFT) quantifies metabolic health by assessing adaptability to dietary changes. This method visualizes individual metabolic flexibility, distinguishing health states within the general population for personalized health insights.

Keywords:
Challenge testData visualizationMetabolic healthNutritional challengePersonalized health

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Area of Science:

  • Metabolic Health
  • Nutritional Science
  • Biomarker Discovery

Background:

  • Metabolic health relies on adapting to dietary changes.
  • The PhenFlex test (PFT) quantifies metabolic processes for homeostasis.
  • PFT is more sensitive than fasting markers for detecting metabolic impairment.

Purpose of the Study:

  • To demonstrate PFT's ability to differentiate health states within the healthy population.
  • To visualize individual metabolic flexibility using a novel 'health space'.
  • To explore variations in phenotypic flexibility across diverse demographics.

Main Methods:

  • 100 healthy subjects (50 male, 50 female) were recruited across age and body fat ranges.
  • Biomarkers assessed glucose, lipid, amino acid, and vitamin metabolism, plus metabolic stress.
  • Individual metabolic flexibility was visualized in a four-axis 'health space'.

Main Results:

  • The 'health space' visualization effectively distinguished health states within the healthy population.
  • Significant differences in metabolic adaptation to PFT were observed between young/lean and old/higher-fat individuals.
  • The visualization intuitively revealed variations in phenotypic flexibility.

Conclusions:

  • The PhenFlex test combined with 'health space' reliably assesses individual health.
  • This approach offers potential for personalized health quantification.
  • Future applications include personalized health advice and monitoring.