Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Study Design in Statistics01:15

Study Design in Statistics

10.1K
A study design is a set of techniques that allow a researcher to collect and analyze data from different variables defined for a specific research problem. Statistics is commonly for effective study design and more robust experiments,
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...
10.1K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

488
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
488
Clinical Trials: Overview01:11

Clinical Trials: Overview

5.1K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.1K
Clinical Trials01:16

Clinical Trials

10.9K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.9K
Case Studies01:22

Case Studies

13.7K
There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
13.7K
Observational Studies01:11

Observational Studies

11.2K
Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
11.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of Perioperative Sleep Characteristics Using Subjective and Objective Methods: A Secondary Analysis of Prospective Cohort Study.

Sleep disorders·2023
Same author

Does the minimal occlusive volume technique provide adequate endotracheal tube cuff pressure to prevent air leakage?: a prospective, randomized, crossover clinical study.

Anesthesia and pain medicine·2020
Same author

Effect of protracted dexamethasone exposure and its withdrawal on rocuronium-induced neuromuscular blockade and sugammadex reversal: an ex vivo rat study.

Scientific reports·2019
Same author

Survival analysis: Part I - analysis of time-to-event.

Korean journal of anesthesiology·2018
Same author

Hypercapnia does not shorten emergence time from propofol anesthesia: a pilot randomized clinical study.

Korean journal of anesthesiology·2018
Same author

Assessment of risk of bias in quasi-randomized controlled trials and randomized controlled trials reported in the <i>Korean Journal of Anesthesiology</i> between 2010 and 2016.

Korean journal of anesthesiology·2017
Same journal

From association to causation: interpreting propensity score-based analyses in real-world evidence.

Korean journal of anesthesiology·2026
Same journal

Video laryngeal mask-guided placement of electromyographic endotracheal tubes for intraoperative neuromonitoring during thyroidectomy: a simulator-based feasibility report.

Korean journal of anesthesiology·2026
Same journal

Amino acids for renal protection: time to implement in clinical practice.

Korean journal of anesthesiology·2026
Same journal

Easy DAO2 index: a novel hemodynamic risk factor for predicting mortality in surgical and critically ill patients.

Korean journal of anesthesiology·2026
Same journal

Association of dexmedetomidine with improved survival in ICU delirium.

Korean journal of anesthesiology·2026
Same journal

Cadaveric investigation of an ultrasound-guided obturator canal approach for obturator nerve block.

Korean journal of anesthesiology·2026
See all related articles

Related Experiment Video

Updated: Feb 17, 2026

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

12.9K

Introduction of a pilot study.

Junyong In1

  • 1Department of Anesthesiology and Pain Medicine, Dongguk University Ilsan Hospital, Goyang, Korea.

Korean Journal of Anesthesiology
|December 12, 2017
PubMed
Summary
This summary is machine-generated.

Pilot studies assess feasibility and safety before large-scale research. This review clarifies their role, ethical considerations, and result interpretation for improved main study design.

Keywords:
FeasibilityMethodologyPilot

More Related Videos

Pilot In Vitro Study to Assess Cleaning Ability and Effects of Different Decontamination Methods on Implant Surfaces
03:10

Pilot In Vitro Study to Assess Cleaning Ability and Effects of Different Decontamination Methods on Implant Surfaces

Published on: November 21, 2025

269
Eye Tracking During A Complex Aviation Task For Insights Into Information Processing
07:48

Eye Tracking During A Complex Aviation Task For Insights Into Information Processing

Published on: April 4, 2025

1.3K

Related Experiment Videos

Last Updated: Feb 17, 2026

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

12.9K
Pilot In Vitro Study to Assess Cleaning Ability and Effects of Different Decontamination Methods on Implant Surfaces
03:10

Pilot In Vitro Study to Assess Cleaning Ability and Effects of Different Decontamination Methods on Implant Surfaces

Published on: November 21, 2025

269
Eye Tracking During A Complex Aviation Task For Insights Into Information Processing
07:48

Eye Tracking During A Complex Aviation Task For Insights Into Information Processing

Published on: April 4, 2025

1.3K

Area of Science:

  • Clinical research methodology
  • Study design and planning

Background:

  • Pilot studies are small-scale preliminary investigations.
  • They precede full-scale research to refine methodology and assess feasibility.

Purpose of the Study:

  • To clarify the role and importance of pilot studies.
  • To address misconceptions and ethical aspects of pilot research.
  • To guide the interpretation of pilot study results.

Main Methods:

  • Review of existing literature on pilot study design and ethics.
  • Discussion of key elements: feasibility, safety, recruitment, randomization, blinding.
  • Exploration of sample size calculation and researcher experience.

Main Results:

  • Pilot studies are crucial for enhancing the quality and efficiency of main studies.
  • They assess treatment safety, recruitment potential, and procedural aspects.
  • They provide essential data for sample size estimation.

Conclusions:

  • Pilot studies are indispensable for rigorous and ethical clinical research.
  • Understanding their purpose and interpretation is key to successful large-scale trials.
  • This review aims to demystify pilot studies and their critical contributions.