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Related Concept Videos

Gene Therapy00:59

Gene Therapy

27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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What is Genetic Engineering?00:49

What is Genetic Engineering?

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Overview
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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In-vitro Mutagenesis01:16

In-vitro Mutagenesis

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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
16.7K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Related Experiment Video

Updated: Feb 17, 2026

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells
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Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells

Published on: February 15, 2019

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Update on GH therapy in adults.

Cesar Luiz Boguszewski1

  • 1Endocrine Division (SEMPR), Department of Internal Medicine, Federal University of Parana, Curitiba, Brazil.

F1000Research
|December 12, 2017
PubMed
Summary

Growth hormone (GH) replacement therapy for adults with GH deficiency (AGHD) is well-studied, but new long-acting preparations offer improved adherence and outcomes. This review updates diagnosis, treatment, and future perspectives for AGHD management.

Area of Science:

  • Endocrinology
  • Pharmacology

Background:

  • Decades of research inform growth hormone (GH) replacement therapy for adults with GH deficiency (AGHD).
  • Existing guidelines offer evidence-based management strategies for AGHD.
  • Gaps in evidence remain for certain aspects of AGHD treatment.

Purpose of the Study:

  • To enhance understanding of AGHD diagnosis and treatment.
  • To provide an update on current therapeutic approaches for AGHD.
  • To explore future perspectives on long-acting GH preparations in AGHD management.

Main Methods:

  • Review of observational studies, clinical trials, systematic reviews, and meta-analyses.
  • Compilation of knowledge into clinical guidelines.
  • Analysis of recent developments in long-acting GH preparations.
Keywords:
IGF-Iadults with GH deficiencygrowth hormone

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Main Results:

  • Established efficacy and safety of GH replacement therapy in AGHD.
  • Identification of areas with moderate or weak evidence for AGHD recommendations.
  • Emergence of long-acting GH preparations offering improved patient adherence.

Conclusions:

  • GH replacement therapy is a cornerstone in AGHD management.
  • Long-acting GH preparations represent a significant advancement, potentially improving clinical outcomes.
  • Continued research is needed to address evidence gaps and optimize AGHD treatment.